Complex interaction between serum folate levels and genetic polymorphisms in folate pathway genes: biomarkers of prostate cancer aggressiveness

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• 作者：Maria D. Jackson (1)
  Marshall K. Tulloch-Reid (2)
  Norma McFarlane-Anderson (3)
  Alexis Watson (4)
  Vestra Seers (5)
  Franklyn I. Bennett (6)
  Brian Egleston (7)
  Camille Ragin (8)
  
• 关键词：Prostate cancer ; Serum folate ; Folate pathway genes ; African ancestry
• 刊名：Genes & Nutrition
• 出版年：2013
• 出版时间：March 2013
• 年：2013
• 卷：8
• 期：2
• 页码：199-207
• 全文大小：206KB
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• 作者单位：Maria D. Jackson (1)
  Marshall K. Tulloch-Reid (2)
  Norma McFarlane-Anderson (3)
  Alexis Watson (4)
  Vestra Seers (5)
  Franklyn I. Bennett (6)
  Brian Egleston (7)
  Camille Ragin (8)
  
  1. Department of Community Health and Psychiatry, University of the West Indies, Mona, Kingston 7, Jamaica
  2. Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston, Jamaica
  3. Department of Basic Medical Sciences, University of the West Indies, Mona Campus, Kingston, Jamaica
  4. Department Biology, Howard University, Washington, DC, USA
  5. Department of Biology, Philander Smith College, Little Rock, AR, USA
  6. Department of Pathology, University of the West Indies, Mona, Kingston, Jamaica
  7. Biostatistics and Bioinformatics, Fox Chase Cancer Center, Philadelphia, PA, USA
  8. Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA, USA
  
• ISSN：1865-3499

文摘

Little is known about the role of folate and polymorphisms associated with folate metabolism on prostate cancer risk in populations of African origin. We examined the relationship between serum folate and prostate cancer and whether any association was modified by genetic polymorphisms for folate metabolism. The study was case–control in design and consisted of 218 men 40-0?years old with newly diagnosed, histologically confirmed prostate cancer and 236 cancer-free men attending the same urology clinics in Jamaica, March 2005–July 2007. Serum folate was measured by an immunoassay method and genomic DNA evaluated for MTHR (C677T and A1298C), MTRR A66G, and MTR A2756G polymorphisms. Mean serum folate concentration was higher among cases (12.3?±?4.1?nmol/L) than controls (9.7?±?4.2?nmol/L). Serum folate concentration showed a positive association with prostate cancer (OR, 4.41; CI, 2.52-.72 per 10?nmol/L) regardless of grade. No interactions were observed between genotype and folate concentration, but a weak gene effect was observed for MTHFR A1298C and low-grade prostate cancer. Larger studies to investigate the role of gene–gene/gene–diet interactions in Black men are needed.