Gender differences in response to cold pressor test assessed with velocity-encoded cardiovascular magnetic resonance of the coronary sinus

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• 作者：Pierre-Julien Moro (1) (2)
  Antonin Flavian (1) (3)
  Alexis Jacquier (1) (3)
  Frank Kober (1)
  Jacques Quilici (2)
  Bénédicte Gaborit (1)
  Jean-Louis Bonnet (2)
  Guy Moulin (3)
  Patrick J Cozzone (1)
  Monique Bernard (1)
  
• 关键词：cold pressor test ; coronary sinus flow ; endothelium ; myocardial blood flow
• 刊名：Journal of Cardiovascular Magnetic Resonance
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：13
• 期：1
• 全文大小：1506KB
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• 作者单位：Pierre-Julien Moro (1) (2)
  Antonin Flavian (1) (3)
  Alexis Jacquier (1) (3)
  Frank Kober (1)
  Jacques Quilici (2)
  Bénédicte Gaborit (1)
  Jean-Louis Bonnet (2)
  Guy Moulin (3)
  Patrick J Cozzone (1)
  Monique Bernard (1)
  
  1. Centre de Résonance Magnétique Biologique et Médicale (CRMBM), UMR 6612 CNRS, Université de la Méditerranée, Faculté de Médecine, 27 Bd Jean Moulin, 13385, Marseille cedex 5, France
  2. Service de Cardiologie, Centre Hospitalo-Universitaire La Timone, 264 rue St Pierre, 13385, Marseille cedex 5, France
  3. Service de Radiologie Cardiovasculaire, Centre Hospitalo-Universitaire La Timone, 264 rue St Pierre, 13385, Marseille cedex 5, France
  

文摘

Background Gender-specific differences in cardiovascular risk are well known, and current evidence supports an existing role of endothelium in these differences. The purpose of this study was to assess non invasively coronary endothelial function in male and female young volunteers by myocardial blood flow (MBF) measurement using coronary sinus (CS) flow quantification by velocity encoded cine cardiovascular magnetic resonance (CMR) at rest and during cold pressor test (CPT). Methods Twenty-four healthy volunteers (12 men, 12 women) underwent CMR in a 3 Tesla MR imager. Coronary sinus flow was measured at rest and during CPT using non breath-hold velocity encoded phase contrast cine-CMR. Myocardial function and morphology were acquired using a cine steady-state free precession sequence. Results At baseline, mean MBF was 0.63 ± 0.23 mL·g-1·min-1 in men and 0.79 ± 0.21 mL·g-1·min-1 in women. During CPT, the rate pressure product in men significantly increased by 49 ± 36% (p < 0.0001) and in women by 52 ± 22% (p < 0.0001). MBF increased significantly in both men and women by 0.22 ± 0.19 mL·g-1·min-1 (p = 0.0022) and by 0.73 ± 0.43 mL·g-1·min-1 (p = 0.0001), respectively. The increase in MBF was significantly higher in women than in men (p = 0.0012). Conclusion CMR coronary sinus flow quantification for measuring myocardial blood flow revealed a higher response of MBF to CPT in women than in men. This finding may reflect gender differences in endothelial-dependent vasodilatation in these young subjects. This non invasive rest/stress protocol may become helpful to study endothelial function in normal physiology and in physiopathology.