Microwave-assisted synthesis of alginate-g-polyvinylpyrrolidone copolymer and its application in controlled drug release

详细信息    查看全文

• 作者：Mustafa Yi?ito?lu (1)
  Gülden Ayd?n (1)
  Nuran I??klan (1)
  
• 关键词：Graft copolymer ; Controlled release ; Drug delivery systems ; Ibuprofen ; Hydrophilic polymers
• 刊名：Polymer Bulletin
• 出版年：2014
• 出版时间：February 2014
• 年：2014
• 卷：71
• 期：2
• 页码：385-414
• 全文大小：1,466 KB
• 作者单位：Mustafa Yi?ito?lu (1)
  Gülden Ayd?n (1)
  Nuran I??klan (1)
  
  1. Department of Chemistry, Faculty of Arts and Sciences, Kirikkale University, Yah?ihan, 71450, Kirikkale, Turkey
  
• ISSN：1436-2449

文摘

The aim of this study is to synthesize graft copolymer (NaAlg-g-PVP) in microwave oven and prepare pH-responsive beads with high entrapment efficiency. For this purpose, PVP was grafted onto sodium alginate using microwave radiation. The copolymer obtained was characterized using FTIR, 1H-NMR, elemental analysis and thermogravimetric analysis. A series of NaAlg-g-PVP beads were prepared as drug delivery matrices for ibuprofen (IB) by cross-linking into beads via glutaraldehyde. The chemical stability of IB after encapsulation into beads was confirmed by FTIR, DSC, and X-RD analysis. Synthesis conditions of beads were optimized by considering entrapment efficiency, particle size, swelling capacity and their release data. Effects of such variables as graft yield and drug/polymer ratio were investigated at 1.2 and 7.4 pH values. Increasing the drug/polymer ratio and extent of cross-linking caused decrease in the IB release. On the other hand, increase in the graft yield led to increase in the IB release as well. The results also showed that NaAlg-g-PVP beads were positive pH-responsive.