Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families

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• 作者：Joan E Bailey-Wilson (1) (32) (7)
  Erica J Childs (1) (2)
  Cheryl D Cropp (1)
  Daniel J Schaid (3)
  Jianfeng Xu (4)
  Nicola J Camp (5)
  Lisa A Cannon-Albright (5) (6)
  James M Farnham (5)
  Asha George (1) (7) (8)
  Isaac Powell (7) (9)
  John D Carpten (10) (7)
  Graham G Giles (11) (12) (13)
  John L Hopper (11) (13)
  Gianluca Severi (11) (12) (13)
  Dallas R English (11) (12) (13)
  William D Foulkes (11) (14)
  Lovise M?hle (11) (15)
  P?l M?ller (11) (15)
  Rosalind Eeles (11) (16)
  Douglas Easton (11) (17)
  Michelle Guy (11) (16)
  Steve Edwards (11) (16)
  Michael D Badzioch (11) (18)
  Alice S Whittemore (19) (20) (21)
  Ingrid Oakley-Girvan (19) (20) (21) (42)
  Chih-Lin Hsieh (19) (22)
  Latchezar Dimitrov (4)
  Janet L Stanford (23) (24)
  Danielle M Karyadi (23) (25)
  Kerry Deutsch (23) (26)
  Laura McIntosh (23) (24)
  Elaine A Ostrander (23) (25)
  Kathleen E Wiley (27)
  Sarah D Isaacs (27)
  Patrick C Walsh (27)
  Stephen N Thibodeau (28)
  Shannon K McDonnell (28)
  Scott Hebbring (28)
  Ethan M Lange (29) (30)
  Kathleen A Cooney (29) (31)
  Teuvo LJ Tammela (32) (33) (34)
  Johanna Schleutker (32) (33) (34)
  Christiane Maier (35) (36) (37)
  Sylvia Bochum (35) (37)
  Josef Hoegel (35) (37)
  Henrik Gr?nberg (38)
  Fredrik Wiklund (38)
  Monica Emanuelsson (39)
  Geraldine Cancel-Tassin (40)
  Antoine Valeri (40)
  Olivier Cussenot (40) (41)
  William B Isaacs (27)
  
• 刊名：BMC Medical Genetics
• 出版年：2012
• 出版时间：December 2012
• 年：2012
• 卷：13
• 期：1
• 全文大小：466KB
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  65. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2350/13/46/prepub
  
• 作者单位：Joan E Bailey-Wilson (1) (32) (7)
  Erica J Childs (1) (2)
  Cheryl D Cropp (1)
  Daniel J Schaid (3)
  Jianfeng Xu (4)
  Nicola J Camp (5)
  Lisa A Cannon-Albright (5) (6)
  James M Farnham (5)
  Asha George (1) (7) (8)
  Isaac Powell (7) (9)
  John D Carpten (10) (7)
  Graham G Giles (11) (12) (13)
  John L Hopper (11) (13)
  Gianluca Severi (11) (12) (13)
  Dallas R English (11) (12) (13)
  William D Foulkes (11) (14)
  Lovise M?hle (11) (15)
  P?l M?ller (11) (15)
  Rosalind Eeles (11) (16)
  Douglas Easton (11) (17)
  Michelle Guy (11) (16)
  Steve Edwards (11) (16)
  Michael D Badzioch (11) (18)
  Alice S Whittemore (19) (20) (21)
  Ingrid Oakley-Girvan (19) (20) (21) (42)
  Chih-Lin Hsieh (19) (22)
  Latchezar Dimitrov (4)
  Janet L Stanford (23) (24)
  Danielle M Karyadi (23) (25)
  Kerry Deutsch (23) (26)
  Laura McIntosh (23) (24)
  Elaine A Ostrander (23) (25)
  Kathleen E Wiley (27)
  Sarah D Isaacs (27)
  Patrick C Walsh (27)
  Stephen N Thibodeau (28)
  Shannon K McDonnell (28)
  Scott Hebbring (28)
  Ethan M Lange (29) (30)
  Kathleen A Cooney (29) (31)
  Teuvo LJ Tammela (32) (33) (34)
  Johanna Schleutker (32) (33) (34)
  Christiane Maier (35) (36) (37)
  Sylvia Bochum (35) (37)
  Josef Hoegel (35) (37)
  Henrik Gr?nberg (38)
  Fredrik Wiklund (38)
  Monica Emanuelsson (39)
  Geraldine Cancel-Tassin (40)
  Antoine Valeri (40)
  Olivier Cussenot (40) (41)
  William B Isaacs (27)
  
  1. Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, 21224, USA
  32. University of Tampere ICPCG Group, Tampere, Finland
  7. African American Hereditary Prostate Cancer ICPCG Group, Phoenix, AZ, USA
  2. Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
  3. Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA
  4. Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA
  5. University of Utah ICPCG Group and Division of Genetic Epidemiology, University of Utah School of Medicine, Salt Lake City, UT, USA
  6. George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA
  8. Fox Chase Cancer Center, Philadelphia, PA, USA
  9. Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA
  10. Translational Genomics Research Institute, Genetic Basis of Human Disease Research Division, Phoenix, AZ, USA
  11. ACTANE consortium, Kragujevac, USA
  12. Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia
  13. Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia
  14. Program in Cancer Genetics, McGill University, Montreal, QC, Canada
  15. Department of Medical Genetics, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway
  16. Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Surrey, UK
  17. Cancer Research UK Genetic Epidemiology Unit, Cambridge, UK
  18. Division of Medical Genetics, University of Washington Medical Center, Seattle, WA, USA
  19. BC/CA/HI ICPCG Group, Stanford, CA, USA
  20. Department of Health Research and Policy, Stanford School of Medicine, Stanford, CA, USA
  21. Stanford Cancer Institute, Stanford School of Medicine, Stanford, CA, USA
  42. Cancer Prevention Institute of California, Kragujevac, USA
  22. Department of Urology and Department of Biochemistry and Molecular Biology, University of Southern California, Los Ageles, CA, USA
  23. FHCRC ICPCG Group, Seattle, WA, USA
  24. Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA
  25. Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
  26. Institute for Systems Biology, Seattle, WA, USA
  27. Johns Hopkins University ICPCG Group and Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
  28. Mayo Clinic, Rochester, MN, USA
  29. University of Michigan ICPCG Group, Ann Arbor, MI, USA
  30. Department of Genetics, University of North Carolina, Chapel Hill, NC, USA
  31. University of Michigan, Ann Arbor, MI, USA
  33. Institute of Biomedical Technology, University of Tampere, Tampere, Finland
  34. Centre for Laboratory Medicine and Department of Urology, Tampere University Hospital, Tampere, Finland
  35. University of Ulm ICPCG Group, Ulm, Germany
  36. Dept of Urology, University of Ulm, Ulm, Germany
  37. Institute of Human Genetics, University of Ulm, Ulm, Germany
  38. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
  39. Oncologic Centre, Ume? University, Ume?, Sweden
  40. CeRePP ICPCG Group, 75020, Paris, France
  41. Hopital Tenon, Assistance Publique-Hopitaux de Paris, 75020, Paris, France
  
• ISSN：1471-2350

文摘

Background Genetic variants are likely to contribute to a portion of prostate cancer risk. Full elucidation of the genetic etiology of prostate cancer is difficult because of incomplete penetrance and genetic and phenotypic heterogeneity. Current evidence suggests that genetic linkage to prostate cancer has been found on several chromosomes including the X; however, identification of causative genes has been elusive. Methods Parametric and non-parametric linkage analyses were performed using 26 microsatellite markers in each of 11 groups of multiple-case prostate cancer families from the International Consortium for Prostate Cancer Genetics (ICPCG). Meta-analyses of the resultant family-specific linkage statistics across the entire 1,323 families and in several predefined subsets were then performed. Results Meta-analyses of linkage statistics resulted in a maximum parametric heterogeneity lod score (HLOD) of 1.28, and an allele-sharing lod score (LOD) of 2.0 in favor of linkage to Xq27-q28 at 138 cM. In subset analyses, families with average age at onset less than 65 years exhibited a maximum HLOD of 1.8 (at 138 cM) versus a maximum regional HLOD of only 0.32 in families with average age at onset of 65 years or older. Surprisingly, the subset of families with only 2- affected men and some evidence of male-to-male transmission of prostate cancer gave the strongest evidence of linkage to the region (HLOD--.24, 134 cM). For this subset, the HLOD was slightly increased (HLOD--.47 at 134 cM) when families used in the original published report of linkage to Xq27-28 were excluded. Conclusions Although there was not strong support for linkage to the Xq27-28 region in the complete set of families, the subset of families with earlier age at onset exhibited more evidence of linkage than families with later onset of disease. A subset of families with 2- affected individuals and with some evidence of male to male disease transmission showed stronger linkage signals. Our results suggest that the genetic basis for prostate cancer in our families is much more complex than a single susceptibility locus on the X chromosome, and that future explorations of the Xq27-28 region should focus on the subset of families identified here with the strongest evidence of linkage to this region.