Normal regulation of elevated plasma ghrelin concentrations in dialysis patients
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  • 作者:Adele Schmidt (1)
    Veronika Fabrizii (2)
    Christina Maier (1)
    Michaela Riedl (1)
    Alice Schmidt (2)
    Harald Kotzmann (1)
    Georg Geyer (3)
    Anton Luger M.D. (1) (3)
  • 关键词:Ghrelin ; appetite ; hemodialysis ; malnutrition
  • 刊名:Wiener klinische Wochenschrift
  • 出版年:2004
  • 出版时间:April 2004
  • 年:2004
  • 卷:116
  • 期:7-8
  • 页码:235-239
  • 全文大小:85KB
  • 参考文献:1. Lowrie EG, Lew NL (1990) Death risk in hemodialysis patients: the predictive value of commonly measured variables and an evaluation of death rate differences between facilities. Am J Kidney Dis 15: 458鈥?82
    2. Druml W (2001) Nutritional management of acute renal failure. Am J Kidney Dis 37 [Suppl 2]: S89鈥?4 CrossRef
    3. Berneis K, Iseli-Schaub J, Garbani E, Meier R, Kiss D (1999) Effects of intradialytic parenteral nutrition in chronic haemodialysis patients with malnutrition: a pilot study. Wien Klin Wochenschr 111: 876鈥?81
    4. Kotzmann H, Yilmaz N, Lercher P, Riedl M, Schmidt A, Schuster E, et al (2001) Differential effects of growth hormone therapy in malnourished hemodialysis patients. Kidney Int 60: 1578鈥?585 CrossRef
    5. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402: 656鈥?60 CrossRef
    6. Arvat E, Di Vito L, Broglio F, Papotti M, Muccioli G, Dieguez C, et al (2000) Preliminary evidence that ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans. J Endocrinol Invest 23: 493鈥?95
    7. Arvat E, Maccario M, Di Vito L, Broglio F, Benso A, Gottero C, et al (2001) Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone. J Clin Endocrinol Metab 86: 1169鈥?174 CrossRef
    8. Schaller G, Schmidt A, Pleiner J, Woloszczuk W, Wolzt M, Luger A (2003) Plasma ghrelin concentrations are not regulated by glucose or insulin: a double-blind, placebo controlled, cross-over clamp study. Diabetes 52: 16鈥?0 CrossRef
    9. Ukkola O (2003) Ghrelin and insulin metabolism. Eur J Clin Invest 33: 183鈥?85 CrossRef
    10. Tsch枚p M, Smiley DL, Heiman ML (2000) Ghrelin induces adiposity in rodents. Nature 407: 908鈥?13 CrossRef
    11. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS (2001) A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50: 1714鈥?719 CrossRef
    12. Tsch枚p M, Weyer C, Tatarini PA, Devanarayan V, Ravussin E, Heiman ML (2001) Circulating ghrelin levels are decreased in human obesity. Diabetes 50: 707鈥?09 CrossRef
    13. Otto B, Cuntz U, Fruehauf E, Wawarta R, Folwaczny C, Riepl RL, et al (2001) Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa. Eur J Endocrinol 145: 669鈥?73 CrossRef
    14. Nagaya N, Uematsu M, Kojima M, Date Y, Nakazato M, Okumura H, et al (2001) Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: relationships between ghrelin and anabolic/catabolic factors. Circulation 104: 2034鈥?038 CrossRef
    15. Tamura H, Kamegai J, Shimizu T, Ishii S, Sugihara H, Oikawa S (2002) Ghrelin stimulates GH but not food intake in arcuate nucleus ablated rats. Endocrinology 143: 3268鈥?275 CrossRef
    16. T枚nshoff B, Blum WF, Mehls O (1997) Derangements of the somatotropic hormone axis in chronic renal failure. Kidney Int 51 [Suppl 58]: S106-S113
    17. Smith DJ, DeFronzo RA (1990) Endocrine dysfunction in chronic renal failure. In: Nissenson AR, Fine RN, Gentile DE (eds) Appleton & Lange, Norwalk, pp 451鈥?97
    18. National Kidney Foundation (1997) DOQI clinical practice guidelines. Am J Kidney Dis 30 [Suppl]: S137-S240
    19. Chapman IM, Bach MA, van Cauter E, Farmer M, Krupa D, Taylor AM, et al (1996) Stimulation of the growth hormone (GH)-insulin-like-growth factor-1 axis by daily oral administration of a GH secretagogue (MK-677) in healthy elderly subjects. J Clin Endocrinol Metab 81: 4249鈥?257 CrossRef
    20. Haffner D, Schaefer F, Nissel R, W眉hl E, T枚nshoff B, Mehls O for the German Study Group for Growth Hormone Treatment in Chronic Renal Failure (2000) Effect of growth hormone treatment on the adult height of children with chronic renal failure. N Engl J Med 343: 923鈥?30 CrossRef
    21. Yoshimoto A, Mori K, Sugawara A, Mukoyama M, Yahata K, Suganami T, et al (2002) Plasma ghrelin and desacyl ghrelin concentrations in renal failure. J Am Soc Nephrol 3: 2748鈥?752 CrossRef
    22. Bergstr枚m J (1999) Regulation of appetite in chronic renal failure. Miner Electrolyte Metab 25: 291鈥?97 CrossRef
    23. Aguilera A, Codoceo R, Selgas R, Garcia P, Picornell M, Diaz C, et al (1998) Anorexigen (TNF-alpha, cholecystokinin) and orexigen (neuropeptide Y) plasma levels in peritoneal dialysis (PD) patients: their relationship with nutritional parameters. Nephrol Dial Transplant 13: 1476鈥?483 CrossRef
    24. Hilkens MGEC, Netea MG, Van der Meer JWM, Koolen MI (2003) Leptin and proinflammatory cytokines in patients undergoing dialysis. Eur J Clin Invest 33: 525鈥?26 CrossRef
    25. Luger A, Kovarik J, Stummvoll HK, Urbanska A, Luger TA (1987) Blood-membrane interaction in hemodialysis leads to increased cytokine production. Kidney Int 32: 84鈥?8 CrossRef
  • 作者单位:Adele Schmidt (1)
    Veronika Fabrizii (2)
    Christina Maier (1)
    Michaela Riedl (1)
    Alice Schmidt (2)
    Harald Kotzmann (1)
    Georg Geyer (3)
    Anton Luger M.D. (1) (3)

    1. Clinical Division of Endocrinology and Metabolism, University of Vienna, General Hospital of Vienna, W盲hringer G眉rtel 18-20, A-1090, Vienna, Austria
    2. Clinical Division of Nephrology and Dialysis, Department of Medicine III, University of Vienna, General Hospital of Vienna, W盲hringer G眉rtel 18-20, A-1090, Vienna, Austria
    3. Ludwig Boltzmann Institute for Experimental Endocrinology, Vienna, Austria
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