Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5 +/↿/em> leukemia
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- 作者：Louise van der Weyden ; George Giotopoulos ; Kim Wong ; Alistair G. Rust…
- 关键词：ETV6 ; RUNX1 ; Pax5 ; JAK/STAT ; Trp53 ; Leukemia ; B ; cell precursor ; Insertional mutagenesis
- 刊名：BMC Cancer
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：15
- 期：1
- 全文大小：1,405 KB
- 刊物主题：Cancer Research; Oncology; Stem Cells; Animal Models; Internal Medicine;
- 出版者：BioMed Central
- ISSN：1471-2407
文摘
Background B-cell precursor acute lymphoblastic leukemia (B-ALL) is amongst the leading causes of childhood cancer-related mortality. Its most common chromosomal aberration is the ETV6-RUNX1 fusion gene, with ~25 % of ETV6-RUNX1 patients also carrying PAX5 alterations.