CNS active ergot alkaloid dihydro derivatives: tritium labelling and characterization

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• 作者：Judith A. Egan ; Richard P. Nugent…
• 关键词：Alkaloid ; Ergot ; Tritium ; Tritium NMR
• 刊名：Journal of Radioanalytical and Nuclear Chemistry
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：310
• 期：2
• 页码：823-827
• 全文大小：595 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nuclear Chemistry
  Physical Chemistry
  Nuclear Physics, Heavy Ions and Hadrons
  Diagnostic Radiology
  Inorganic Chemistry
  
• 出版者：Akad茅miai Kiad贸, co-published with Springer Science+Business Media B.V., Formerly Kluwer Academic
• ISSN：1588-2780
• 卷排序：310

文摘

The ergot alkaloids are an important class of medicinally useful substances and this report describes the high specific activity tritium labelling of two dihydro derivatives; namely, dihydroergotamine and dihydrobromocriptine. The former was prepared by the direct tritiation of ergotamine itself. However, efforts to perform an analogous direct tritiation on bromocriptine were unsuccessful and a multistep synthesis was required.