Allografts supercharged with bone-marrow-derived mesenchymal stem cells possess equivalent osteogenic capacity to that of autograft: a study with long-term follow-ups of human biopsies

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• 作者：Philippe Hernigou ; Arnaud Dubory ; François Roubineau…
• 关键词：Mesenchymal stem cells ; Allografts ; Autografts ; Hip revision
• 刊名：International Orthopaedics
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：41
• 期：1
• 页码：127-132
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Orthopedics;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-5195
• 卷排序：41

文摘

PurposeBone-marrow-derived mesenchymal stem cells (BM-MSCs) have been proposed to enhance bone formation in allografts. However, it is not known whether a combination of MSCs, contained in bone marrow concentrate (BMC) and structural allograft could be better than an allograft without MSCs and equivalent to a femoral head autograft in terms of histologic bone formation and long-term cellularity in the graft. After ten years of follow-up, three types of grafts: those initially loaded with BM-MSCs; dead, irradiated allografts; autografts.