The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice

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• 作者：Clyde W. Hodge ; Michael F. Miles ; Amanda C. Sharko ; Rebekah A. Stevenson ; Jennie R. Hillmann ; Veronique Lepoutre ; Joyce Besheer and Jason P. Schroeder
• 关键词：mGluR5 ; mGluR1 ; mGluR2/3 ; MPEP ; Ethanol self ; administration ; Reinforcement ; Alcohol drinking ; Mice
• 刊名：Psychopharmacology
• 出版年：2006
• 出版时间：January 2006
• 年：2006
• 卷：183
• 期：4
• 页码：429-438
• 全文大小：263 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2072

文摘

Rationale Many of the biochemical, physiological, and behavioral effects of ethanol are known to be mediated by ionotropic glutamate receptors. Emerging evidence implicates metabotropic glutamate receptors (mGluRs) in the biobehavioral effects of ethanol and other drugs of abuse, but there is little information regarding the role of mGluRs in the reinforcing effects of ethanol.