Oral antiarrhythmic drugs in converting recent onset atrial fibrillation

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• 作者：Vera H.M. Deneer ; Marieke B.I. Borgh ; J. Herre Kingma ; Loraine Lie-A-Huen and Jacobus R.B.J. Brouwers
• 关键词：Atrial fibrillation ; Amiodarone ; Antiarrhythmic drugs ; Digoxin ; Episodic treatment ; Flecainide ; Propafenone ; Quinidine ; Sotalol ; Verapamil
• 刊名：Pharmacy World and Science
• 出版年：2004
• 出版时间：April, 2004
• 年：2004
• 卷：26
• 期：2
• 页码：66-78
• 全文大小：116.1 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Pharmacy
  
• 出版者：Springer Netherlands
• ISSN：1573-739X

文摘

Aim: This article reviews clinical studies on oral antiarrhythmic drugs in converting recent onset atrial fibrillation. An oral loading dose of an antiarrhythmic drug for cardioversion of atrial fibrillation could be an option, due to its simplicity, both for patients admitted to outpatient departments and for episodic treatment by self administration outside the hospital. The latter treatment strategy has recently been pointed out by the American College of Cardiology, the American Heart Association and the European Society of Cardiology as the pill in the pocket approach.Methods: Articles were identified by Medline 1966 to November 2001 and Embase 1966 to November 2001. Randomized studies of oral antiarrhythmic drugs versus placebo or comparative treatment, which are written in the English language, were selected. Non-randomized or non-comparative studies were selected if the results of an analysis to identify predictors for successful conversion are described. The review of clinical trials is followed by a description of pharmacokinetic parameters of the antiarrhythmic drugs.