Different Epidemic Potentials of the HIV-1B and C Subtypes
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- 作者：Marco Salemi ; Tulio de Oliveira ; Marcelo A. Soares ; Oliver Pybus ; Ana T. Dumans ; Anne-Mieke Vandamme ; Amilcar Tanuri ; Sharon Cassol and Walter M. Fitch
- 关键词：Epidemic potential ; HIV ; 1B ; HIV ; 1C ; Brazil ; South Africa ; AIDS
- 刊名：Journal of Molecular Evolution
- 出版年：2005
- 出版时间：May 2005
- 年：2005
- 卷：60
- 期：5
- 页码：598-605
- 全文大小：254 KB
文摘
HIV, the cause of AIDS in humans, is characterized by great genetic heterogeneity. In particular, HIV-1 group M subtypes are responsible for most of the infections worldwide. We investigate the demographic history of HIV-1B and HIV-1C subtypes in South Africa and Brazil using both a parametric and a nonparametric approach based on coalescent theory. Our results show that although both subtypes are spreading exponentially in Brazil, the HIV-1C growth rate is about twice that of Brazilian HIV-1B or South African HIV-1C, providing evidence, for the first time, of a different epidemic potential between two HIV-1 subtypes. The present study not only may have important consequences for devising future vaccination and therapeutic strategies, but also offers additional evidence that skyline plots are indeed a simple and powerful tool for monitoring and predicting the behavior of viral epidemics.