Impaired Gas Exchange at Birth and Risk of Intellectual Disability and Autism: A Meta-analysis

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• 作者：Amirhossein Modabbernia ; Josephine Mollon…
• 关键词：Asphyxia ; Autism ; Hypoxia ; Intellectual disability ; Neonatal ; Perinatal
• 刊名：Journal of Autism and Developmental Disorders
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：46
• 期：5
• 页码：1847-1859
• 全文大小：1,118 KB
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• 作者单位：Amirhossein Modabbernia (1) (2) (3)
  Josephine Mollon (1) (4)
  Paolo Boffetta (5) (6)
  Abraham Reichenberg (1) (2) (3) (7)
  
  1. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY, USA
  2. Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  3. Seaver Autism Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  4. Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King’s College London, London, UK
  5. Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  6. Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  7. Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  
• 刊物类别：Behavioral Science
• 刊物主题：Psychology
  Child and School Psychology
  Pediatrics
  
• 出版者：Springer Netherlands
• ISSN：1573-3432

文摘

We conducted meta-analyses of 67 studies on the association between neonatal proxies of impaired gas exchange and intellectual disability (ID) or autism spectrum disorders (ASD). Neonatal acidosis was associated with an odds ratio (OR) of 3.55 [95 % confidence interval (95 % CI) 2.23–5.49] for ID and an OR of 1.10 (95 % CI 0.91–1.31) for ASD. Children with a 5-min Apgar score of <7 had an OR of 5.39 (95 % CI 3.84–7.55) for ID and an OR of 1.67 (95 % CI 1.34–2.09) for ASD. O2 treatment was associated with an OR of 4.32 (95 % CI 3.23–5.78) for ID and an OR of 2.02 (95 % CI 1.45 to 2.83) for ASD. Our meta-analysis demonstrates an increased risk of ID and (to a lesser extent) ASD in children with neonatal hypoxia. Moreover, our findings raise the possibility that concomitant ID might account for the observed association between the gas exchange proxies and ASD.