Comparison of the effects of fibrates versus statins on plasma lipoprotein(a) concentrations: a systematic review and meta-analysis of head-to-head randomized controlled trials
详细信息 查看全文
- 作者：Amirhossein Sahebkar ; Luis E. Simental-Mendía ; Gerald F. Watts…
- 关键词：Coronary heart disease ; PPAR ; α ; 3 ; hydroxy ; 3 ; methyl ; glutaryl ; CoA ; Apolipoprotein(a) ; Randomized controlled trial ; Combination therapy
- 刊名：BMC Medicine
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：15
- 期：1
- 全文大小：2058KB
- 刊物主题：Medicine/Public Health, general; Biomedicine, general;
- 出版者：BioMed Central
- ISSN：1741-7015
- 卷排序：15
文摘
BackgroundRaised plasma lipoprotein(a) (Lp(a)) concentration is an independent and causal risk factor for atherosclerotic cardiovascular disease. Several types of pharmacological approaches are under evaluation for their potential to reduce plasma Lp(a) levels. There is suggestive evidence that statins and fibrates, two frequently employed lipid-lowering drugs, can lower plasma Lp(a). The present study aims to compare the efficacy of fibrates and statins in reducing plasma concentrations of Lp(a) using a meta-analysis of randomized head-to-head trials.