The associations between the MCP-1 ?518 A/G polymorphism and ischemic heart disease and ischemic stroke: a meta-analysis of 28 research studies involving 21,524 individuals

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• 作者：Gaojun Cai ; Bifeng Zhang ; Weijin Weng ; Ganwei Shi…
• 关键词：MCP ; 1 ; Polymorphism ; Ischemic heart disease ; Ischemic stroke ; Meta ; analysis
• 刊名：Molecular Biology Reports
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：42
• 期：5
• 页码：997-1012
• 全文大小：2,937 KB
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• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Animal Anatomy, Morphology and Histology
  Animal Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-4978

文摘

Epidemiologic studies have been performed to explore the relationship between MCP-1 polymorphism and ischemic heart disease (IHD) and ischemic stroke (IS). But, the results are not consistent. Because of the poor effect of each individual study, we’ve performed a systematic review and a meta-analysis. A comprehensive search was carried out from PubMed, Embase, Foreign Medical Journal Service (FMJS), China National Knowledge Infrastructure and Wanfang Data. Odds ratios (OR) with 95?% confidence interval (CI) were used to evaluate the strength of associations between the MCP-1 A-2518G polymorphism (rs1024611) and IHD and IS susceptibilities. The pooled OR was calculated by the allelic model (G vs A), the additive model (GG vs AA), the dominant model (GG+GA vs AA) and the recessive model (GG vs AA+GA), respectively. The homogeneity among studies was checked using Cochrane Q statistic. The stability of results was checked by one-way sensitivity analysis. The publication bias between studies was examined by Begg’s funnel plots and Egger’s test. 28 eligible case–control studies met all the criteria and were involved in the present meta-analysis, including a total of 8,901 cases and 12,623 controls. Overall, the MCP-1 A-2518G polymorphism was significantly associated with the IHD susceptibility. The pooled OR was 1.27 (95?% CI 1.09-.48, P?=?0.002) in the dominant model, 1.20 (95?% CI 1.07-.35, P?=?0.001) in the allelic model, 1.25 (95?% CI 1.05-.50, P?=?0.015) in the recessive model and 1.39 (95?% CI 1.10-.75, P?=?0.005) in the additive model. At the same time, the MCP-1 A-2518G polymorphism was significantly associated with the IS susceptibility. The pooled OR was 1.72 (95?% CI 1.12-.65, P?=?0.013) in the dominant model, 1.39 (95?% CI 1.12-.74, P?=?0.003) in the allelic model, 1.59 (95?% CI 1.30-.93, P?=?0.000) in the recessive model, and 2.33 (95?% CI 1.76-.08, P?=?0.000) in the additive model, respectively. No significant publication bias was found in the present meta-analysis. The results of the present meta-analysis suggest that MCP-1 gene A-2518G polymorphism may be associated with the IHD and IS susceptibilities. But the positive result exists in relatively small sample size subgroup.