Performance of computer-based analysis using temporal subtraction to assess joint space narrowing progression in rheumatoid patients

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• 作者：Shota Ichikawa ; Tamotsu Kamishima ; Kenneth Sutherland…
• 关键词：Rheumatoid arthritis ; Joint space narrowing ; Computer ; based joint space analysis ; Temporal subtraction
• 刊名：Rheumatology International
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：36
• 期：1
• 页码：101-108
• 全文大小：626 KB
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• 作者单位：Shota Ichikawa (1)
  Tamotsu Kamishima (2)
  Kenneth Sutherland (3)
  Takanobu Okubo (4)
  Kou Katayama (4)
  
  1. Graduate School of Health Sciences, Hokkaido University, North 12 West 5, Kita-ku, Sapporo, 060-0812, Japan
  2. Faculty of Health Sciences, Hokkaido University, North 12 West 5, Kita-ku, Sapporo, 060-0812, Japan
  3. Graduate School of Medicine, Hokkaido University, North 15, West 7, Kita-ku, Sapporo, 060-8638, Japan
  4. Katayama Orthopedic Rheumatology Clinic, Toyooka13-4-5-17, Asahikawa, 078-8243, Japan
  
• 刊物主题：Rheumatology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1437-160X

文摘

Our computer-based method can detect the chronological change in joint space width between baseline and follow-up images as the joint space difference index (JSDI). The aim of this study was to verify the sensitivity and specificity of our computer-based method in assessment of joint space narrowing progression in rheumatoid patients. Twenty-seven patients (24 women and 3 men) with rheumatoid arthritis underwent radiography of the bilateral hand at baseline and at 1 year. The joint space narrowing (JSN) of a total of 252 metacarpophalangeal (MCP) joints and 229 carpal joints was assessed by our computer-based method, setting the Sharp/van der Heijde method as the gold standard. We constructed a receiver operating characteristic curve by using the Sharp/van der Heijde method as the gold standard and set the optimal cutoff on JSDI for MCP, carpal, and MCP/carpal joints. We then calculated the sensitivity and specificity for each cutoff in assessment of JSN progression. At the most discriminant cutoff, the sensitivity and specificity of the computer-based method for MCP joints was 78.6 versus 85.3 %, respectively (AUC = 0.837; P < 0.001). Carpal joints revealed a lower sensitivity and specificity with 64.7 and 86.8 % (AUC = 0.775; P < 0.001). Furthermore, the sensitivity and specificity for MCP/carpal joints was 71.0 versus 83.6 %, respectively (AUC = 0.778; P < 0.001). The computer-based method presented a reliable assessment of JSN progression with high sensitivity and specificity and may be useful in follow-up assessment of the joint damage in rheumatoid patients.