Clinicopathologic characteristics and therapeutic responses of Chinese patients with non-small cell lung cancer who harbor an anaplastic lymphoma kinase rearrangement

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• 作者：Sha Fu ; Hai-Yun Wang ; Fang Wang ; Ma-Yan Huang ; Ling Deng…
• 关键词：Anaplastic lymphoma kinase rearrangement ; Non ; small cell lung cancer ; Fluorescence in situ hybridization ; Pathology
• 刊名：Chinese Journal of Cancer
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：34
• 期：3
• 全文大小：1445KB
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• 作者单位：Sha Fu (1) (4)
  Hai-Yun Wang (2)
  Fang Wang (1) (4)
  Ma-Yan Huang (3)
  Ling Deng (4)
  Xiao Zhang (4)
  Zu-Lu Ye (4)
  Jian-Yong Shao (1) (4)
  
  1. State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, P. R. China
  4. Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center, 21 Qing Cai Gang Road, Guangzhou, Guangdong, 510060, P. R. China
  2. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177, Stockholm, Sweden
  3. Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, P. R. China
  
• 刊物类别：Oncology;
• 刊物主题：Oncology;
• 出版者：BioMed Central
• ISSN：1944-446X

文摘

Introduction The rearrangement of the anaplastic lymphoma kinase (ALK) gene accounts for approximately 1%鈥?% of lung adenocarcinoma cases and defines a molecular subgroup of tumors characterized by clinical sensitivity to ALK inhibitors such as crizotinib. This study aimed to identify the relationship between ALK rearrangement and the clinicopathologic characteristics of non-small cell lung cancer (NSCLC) and to analyze the therapeutic responses of crizotinib and conventional chemotherapy to ALK rearrangement in NSCLC patients.