The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cells

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• 作者：Israa Salem ; Manal Alsalahi ; Inna Chervoneva ; Lucy D. Aburto…
• 关键词：CEP ; 37440 ; FAK1 ; ALK ; IBC ; Inflammatory breast cancer ; Triple ; negative breast cancer ; TNBC
• 刊名：Breast Cancer Research
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：18
• 期：1
• 全文大小：2,746 KB
• 刊物主题：Cancer Research; Oncology;
• 出版者：BioMed Central
• ISSN：1465-5411

文摘

Background Inflammatory breast cancer (IBC) is an aggressive type of advanced breast cancer with a poor prognosis. We recently found that focal adhesion kinase 1 (FAK1) is upregulated and phosphorylated (active) in IBC. In this study, we investigated the effect of CEP-37440, a dual inhibitor of FAK1 and anaplastic lymphoma kinase (ALK), using human IBC cell lines and preclinical models of IBC.