Disruption of structural covariance networks for language in autism is modulated by verbal ability
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- 作者：Megha Sharda ; Budhachandra S. Khundrakpam ; Alan C. Evans…
- 关键词：ASD ; Verbal IQ ; Language ; Brain asymmetry ; Structural covariance
- 刊名：Brain Structure and Function
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：221
- 期：2
- 页码：1017-1032
- 全文大小：4,573 KB
- 参考文献：Abrams DA, Lynch CJ, Cheng KM et al (2013) Underconnectivity between voice-selective cortex and reward circuitry in children with autism. Proc Natl Acad Sci USA 110:12060–12065. doi:10.1073/pnas.1302982110 PubMed PubMedCentral CrossRef
Ad-Dab’bagh Y, Einarson D, Lyttelton O et al (2006) The CIVET image-processing environment: a fully automated comprehensive pipeline for anatomical neuroimaging research. In: 12th Annual meeting of the Organization for Human Brain Mapping
Alexander-Bloch A, Giedd JN, Bullmore E (2013a) Imaging structural co-variance between human brain regions. Nat Rev Neurosci 14:322–336. doi:10.1038/nrn3465 PubMed PubMedCentral CrossRef
Alexander-Bloch A, Raznahan A, Bullmore E, Giedd J (2013b) The convergence of maturational change and structural covariance in human cortical networks. J Neurosci 33:2889–2899. doi:10.1523/JNEUROSCI.3554-12.2013 PubMed PubMedCentral CrossRef
American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders, 4th edn. Washington, DC
American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Publishing, Arlington
Anderson JS, Nielsen JA, Froehlich AL et al (2011) Functional connectivity magnetic resonance imaging classification of autism. Brain 134:3742–3754. doi:10.1093/brain/awr263 PubMed CrossRef
Bassett DS, Bullmore E, Verchinski BA et al (2008) Hierarchical organization of human cortical networks in health and schizophrenia. J Neurosci 28:9239–9248. doi:10.1523/JNEUROSCI.1929-08.2008 PubMed PubMedCentral CrossRef
Belmonte MK, Allen G, Beckel-Mitchener A et al (2004) Autism and abnormal development of brain connectivity. J Neurosci 24:9228–9231. doi:10.1523/JNEUROSCI.3340-04.2004 PubMed CrossRef
Bernhardt BC, Rozen DA, Worsley KJ et al (2009) Thalamo-cortical network pathology in idiopathic generalized epilepsy: insights from MRI-based morphometric correlation analysis. Neuroimage 46:373–381PubMed CrossRef
Bernhardt BC, Klimecki OM, Leiberg S, Singer T (2013a) Structural covariance networks of the dorsal anterior insula predict females’ individual differences in empathic responding. Cereb Cortex 24:2189–2198. doi:10.1093/cercor/bht072 PubMed CrossRef
Bernhardt BC, Valk SL, Silani G et al (2013b) Selective disruption of sociocognitive structural brain networks in autism and alexithymia. Cereb Cortex. doi:10.1093/cercor/bht182
Bullmore E, Sporns O (2009) Complex brain networks: graph theoretical analysis of structural and functional systems. Nat Rev Neurosci 10:186–198. doi:10.1038/nrn2575 PubMed CrossRef
Cardinale RC, Shih P, Fishman I et al (2013) Pervasive rightward asymmetry shifts of functional networks in autism spectrum disorder. JAMA psychiatry 70:975–982. doi:10.1001/jamapsychiatry.2013.382 PubMed PubMedCentral CrossRef
Chen R, Jiao Y, Herskovits EH (2011) Structural MRI in autism spectrum disorder. Pediatr Res 69:63R–68R. doi:10.1203/PDR.0b013e318212c2b3 PubMed PubMedCentral CrossRef
Cheverud J (1984) Quantitative genetics and developmental constraints on evolution by selection. J Theor Biol 110:155–171PubMed CrossRef
Chung MK, Worsley KJ, Paus T et al (2001) A unified statistical approach to deformation-based morphometry. Neuroimage 14:595–606. doi:10.1006/nimg.2001.0862 PubMed CrossRef
Chung MK, Worsley KJ, Nacewicz BM et al (2010) General multivariate linear modeling of surface shapes using SurfStat. Neuroimage 53:491–505. doi:10.1016/j.neuroimage.2010.06.032 PubMed PubMedCentral CrossRef
Collins DL, Holmes CJ, Peters TM, Evans AC (1995) Automatic 3-D model-based neuroanatomical segmentation. Hum Brain Mapp 3:190–208. doi:10.1002/hbm.460030304 CrossRef
Conturo TE, Lori NF, Cull TS et al (1999) Tracking neuronal fiber pathways in the living human brain. Proc Natl Acad Sci USA 96:10422–10427PubMed PubMedCentral CrossRef
Courchesne E, Pierce K (2005) Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnection. Curr Opin Neurobiol 15:225–230. doi:10.1016/j.conb.2005.03.001 PubMed CrossRef
Courchesne E, Pierce K, Schumann CM et al (2007) Mapping early brain development in autism. Neuron 56:399–413. doi:10.1016/j.neuron.2007.10.016 PubMed CrossRef
De Fossé L, Hodge SM, Makris N et al (2004) Language-association cortex asymmetry in autism and specific language impairment. Ann Neurol 56:757–766. doi:10.1002/ana.20275 PubMed CrossRef
Dinstein I, Pierce K, Eyler L et al (2011) Disrupted neural synchronization in toddlers with autism. Neuron 70:1218–1225. doi:10.1016/j.neuron.2011.04.018 PubMed PubMedCentral CrossRef
Ecker C, Murphy D (2014) Neuroimaging in autism-from basic science to translational research. Nat Rev Neurol 10:82–91. doi:10.1038/nrneurol.2013.276 PubMed CrossRef
Ecker C, Ronan L, Feng Y et al (2013) Intrinsic gray-matter connectivity of the brain in adults with autism spectrum disorder. Proc Natl Acad Sci USA 110:13222–13227. doi:10.1073/pnas.1221880110 PubMed PubMedCentral CrossRef
Ecker C, Shahidiani A, Feng Y et al (2014) The effect of age, diagnosis, and their interaction on vertex-based measures of cortical thickness and surface area in autism spectrum disorder. J Neural Transm. doi:10.1007/s00702-014-1207-1 PubMed
Evans AC (2013) Networks of anatomical covariance. Neuroimage 80:489–504. doi:10.1016/j.neuroimage.2013.05.054 PubMed CrossRef
Evans A, Collins D, Millst S et al (1993) 3D statistical neuroanatomical models from 305 MRI volumes. IEEE-Nuclear science symposium and medical imaging conference IEEE conference record, pp 1813–1817
Eyler LT, Pierce K, Courchesne E (2012) A failure of left temporal cortex to specialize for language is an early emerging and fundamental property of autism. Brain 135:949–960. doi:10.1093/brain/awr364 PubMed PubMedCentral CrossRef
Flagg EJ, Cardy JEO, Roberts W, Roberts TPL (2005) Language lateralization development in children with autism: insights from the late field magnetoencephalogram. Neurosci Lett 386:82–87. doi:10.1016/j.neulet.2005.05.037 PubMed CrossRef
Fletcher PT, Whitaker RT, Tao R et al (2010) Microstructural connectivity of the arcuate fasciculus in adolescents with high-functioning autism. Neuroimage 51:1117–1125. doi:10.1016/j.neuroimage.2010.01.083 PubMed PubMedCentral CrossRef
Fonov V, Evans AC, Botteron K et al (2011) Unbiased average age-appropriate atlases for pediatric studies. Neuroimage 54:313–327. doi:10.1016/j.neuroimage.2010.07.033 PubMed PubMedCentral CrossRef
Gong G, He Y, Chen ZJ, Evans AC (2012) Convergence and divergence of thickness correlations with diffusion connections across the human cerebral cortex. Neuroimage 59:1239–1248. doi:10.1016/j.neuroimage.2011.08.017 PubMed CrossRef
Greimel E, Nehrkorn B, Schulte-Rüther M et al (2013) Changes in grey matter development in autism spectrum disorder. Brain Struct Funct 218:929–942. doi:10.1007/s00429-012-0439-9 PubMed PubMedCentral CrossRef
He Y, Chen Z, Evans A (2008) Structural insights into aberrant topological patterns of large-scale cortical networks in Alzheimer’s disease. J Neurosci 28:4756–4766. doi:10.1523/JNEUROSCI.0141-08.2008 PubMed CrossRef
Herbert MR, Ziegler DA, Deutsch CK et al (2005) Brain asymmetries in autism and developmental language disorder: a nested whole
ain analysis. Brain 128:213–226. doi:10.1093/brain/awh330 PubMed CrossRef
Hickok G (2009) The functional neuroanatomy of language. Phys Life Rev 6:121–143. doi:10.1016/j.plrev.2009.06.001 PubMed PubMedCentral CrossRef
Hickok G, Poeppel D (2000) Towards a functional neuroanatomy of speech perception. Trends Cogn Sci 4:131–138PubMed CrossRef
Hickok G, Poeppel D (2007) The cortical organization of speech processing. Nat Rev Neurosci 8:393–402. doi:10.1038/nrn2113 PubMed CrossRef
Hughes JR (2012) The savant syndrome and its possible relationship to epilepsy. Adv Exp Med Biol 724:332–343. doi:10.1007/978-1-4614-0653-2_25 PubMed CrossRef
Hyde KL, Samson F, Evans AC, Mottron L (2010) Neuroanatomical differences in brain areas implicated in perceptual and other core features of autism revealed by cortical thickness analysis and voxel-based morphometry. Hum Brain Mapp 31:556–566. doi:10.1002/hbm.20887 PubMed
Jeste SS, Geschwind DH (2014) Disentangling the heterogeneity of autism spectrum disorder through genetic findings. Nat Rev Neurol. doi:10.1038/nrneurol.2013.278 PubMedCentral
Jiao Y, Chen R, Ke X et al (2010) Predictive models of autism spectrum disorder based on brain regional cortical thickness. Neuroimage 50:589–599. doi:10.1016/j.neuroimage.2009.12.047 PubMed PubMedCentral CrossRef
Joseph RM, Fricker Z, Fenoglio A et al (2014) Structural asymmetries of language-related gray and white matter and their relationship to language function in young children with ASD. Brain Imaging Behav 8:60–72. doi:10.1007/s11682-013-9245-0 PubMed CrossRef
Jou RJ, Minshew NJ, Keshavan MS et al (2010) Enlarged right superior temporal gyrus in children and adolescents with autism. Brain Res 1360:205–212. doi:10.1016/j.brainres.2010.09.005 PubMed PubMedCentral CrossRef
Just MA, Cherkassky VL, Keller TA, Minshew NJ (2004) Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity. Brain 127:1811–1821. doi:10.1093/brain/awh199 PubMed CrossRef
Kabani N, Le Goualher G, MacDonald D, Evans AC (2001) Measurement of cortical thickness using an automated 3-D algorithm: a validation study. Neuroimage 13:375–380. doi:10.1006/nimg.2000.0652 PubMed CrossRef
Kana RK, Keller TA, Cherkassky VL et al (2006) Sentence comprehension in autism: thinking in pictures with decreased functional connectivity. Brain 129:2484–2493. doi:10.1093/brain/awl164 PubMed PubMedCentral CrossRef
Kana RK, Libero LE, Moore MS (2011) Disrupted cortical connectivity theory as an explanatory model for autism spectrum disorders. Phys Life Rev 8:410–437. doi:10.1016/j.plrev.2011.10.001 PubMed CrossRef
Kelly C, Toro R, Di Martino A et al (2012) A convergent functional architecture of the insula emerges across imaging modalities. Neuroimage 61:1129–1142. doi:10.1016/j.neuroimage.2012.03.021 PubMed PubMedCentral CrossRef
Keown CL, Shih P, Nair A et al (2013) Local functional overconnectivity in posterior brain regions is associated with symptom severity in autism spectrum disorders. Cell Rep 5:567–572. doi:10.1016/j.celrep.2013.10.003 PubMed CrossRef
Khundrakpam BS, Reid A, Brauer J et al (2013) Developmental changes in organization of structural brain networks. Cereb Cortex 23:2072–2085. doi:10.1093/cercor/bhs187 PubMed PubMedCentral CrossRef
Kim JS, Singh V, Lee JK et al (2005) Automated 3-D extraction and evaluation of the inner and outer cortical surfaces using a Laplacian map and partial volume effect classification. Neuroimage 27:210–221. doi:10.1016/j.neuroimage.2005.03.036 PubMed CrossRef
Knaus TA, Silver AM, Kennedy M et al (2010) Language laterality in autism spectrum disorder and typical controls: a functional, volumetric, and diffusion tensor MRI study. Brain Lang 112:113–120. doi:10.1016/j.bandl.2009.11.005 PubMed PubMedCentral CrossRef
Lai G, Pantazatos SP, Schneider H, Hirsch J (2012) Neural systems for speech and song in autism. Brain 135:961–975. doi:10.1093/brain/awr335 PubMed PubMedCentral CrossRef
Lee JK, Lee J-M, Kim JS et al (2006) A novel quantitative cross-validation of different cortical surface reconstruction algorithms using MRI phantom. Neuroimage 31:572–584. doi:10.1016/j.neuroimage.2005.12.044 PubMed CrossRef
Lee JE, Bigler ED, Alexander AL et al (2007) Diffusion tensor imaging of white matter in the superior temporal gyrus and temporal stem in autism. Neurosci Lett 424:127–132. doi:10.1016/j.neulet.2007.07.042 PubMed CrossRef
Lerch JP, Evans AC (2005) Cortical thickness analysis examined through power analysis and a population simulation. Neuroimage 24:163–173. doi:10.1016/j.neuroimage.2004.07.045 PubMed CrossRef
Lerch JP, Worsley K, Shaw WP et al (2006) Mapping anatomical correlations across cerebral cortex (MACACC) using cortical thickness from MRI. Neuroimage 31:993–1003. doi:10.1016/j.neuroimage.2006.01.042 PubMed CrossRef
Lewis JD, Evans AC, Pruett JR et al (2014) Network inefficiencies in autism spectrum disorder at 24 months. Transl Psychiatry 4:e388. doi:10.1038/tp.2014.24 PubMed PubMedCentral CrossRef
Lindell AK, Hudry K (2013) Atypicalities in cortical structure, handedness, and functional lateralization for language in autism spectrum disorders. Neuropsychol Rev 23:257–270. doi:10.1007/s11065-013-9234-5 PubMed CrossRef
Lord C, Risi S, Lambrecht L et al (2000) The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord 30:205–223PubMed CrossRef
MacDonald D, Kabani N, Avis D, Evans AC (2000) Automated 3-D extraction of inner and outer surfaces of cerebral cortex from MRI. Neuroimage 12:340–356. doi:10.1006/nimg.1999.0534 PubMed CrossRef
Mason RA, Williams DL, Kana RK et al (2008) Theory of Mind disruption and recruitment of the right hemisphere during narrative comprehension in autism. Neuropsychologia 46:269–280. doi:10.1016/j.neuropsychologia.2007.07.018 PubMed PubMedCentral CrossRef
Maximo JO, Cadena EJ, Kana RK (2014) The implications of brain connectivity in the neuropsychology of autism. Neuropsychol Rev 24:16–31. doi:10.1007/s11065-014-9250-0 PubMed PubMedCentral CrossRef
Mechelli A, Friston KJ, Frackowiak RS, Price CJ (2005) Structural covariance in the human cortex. J Neurosci 25:8303–8310. doi:10.1523/JNEUROSCI.0357-05.2005 PubMed CrossRef
Miles JH (2011) Autism spectrum disorders–a genetics review. Genet Med 13:278–294. doi:10.1097/GIM.0b013e3181ff67ba PubMed CrossRef
Minshew NJ, Keller TA (2010) NIH Public Access. 23:124–130. doi:10.1097/WCO.0b013e32833782d4
Mody M, Belliveau JW (2013) Speech and language impairments in autism: insights from behavior and neuroimaging. N Am J Med Sci (Boston) 5:157–161CrossRef
Morán MA, Mufson EJ, Mesulam MM (1987) Neural inputs into the temporopolar cortex of the rhesus monkey. J Comp Neurol 256:88–103. doi:10.1002/cne.902560108 PubMed CrossRef
Mottron L, Dawson M, Soulières I et al (2006) Enhanced perceptual functioning in autism: an update, and eight principles of autistic perception. J Autism Dev Disord 36:27–43. doi:10.1007/s10803-005-0040-7 PubMed CrossRef
Müller R-A, Shih P, Keehn B et al (2011) Underconnected, but how? A survey of functional connectivity MRI studies in autism spectrum disorders. Cereb Cortex 21:2233–2243. doi:10.1093/cercor/bhq296 PubMed PubMedCentral CrossRef
Nair A, Keown CL, Datko M et al (2014) Impact of methodological variables on functional connectivity findings in autism spectrum disorders. Hum Brain Mapp. doi:10.1002/hbm.22456 PubMed
Rapin I, Dunn M (2003) Update on the language disorders of individuals on the autistic spectrum. Brain Dev 25:166–172. doi:10.1016/S0387-7604(02)00191-2 PubMed CrossRef
Raznahan A, Lerch JP, Lee N et al (2011) Patterns of coordinated anatomical change in human cortical development: a longitudinal neuroimaging study of maturational coupling. Neuron 72:873–884. doi:10.1016/j.neuron.2011.09.028 PubMed CrossRef
Redcay E, Courchesne E (2008) Deviant functional magnetic resonance imaging patterns of brain activity to speech in 2-3-year-old children with autism spectrum disorder. Biol Psychiatry 64:589–598. doi:10.1016/j.biopsych.2008.05.020 PubMed PubMedCentral CrossRef
Rimol LM, Panizzon MS, Fennema-Notestine C et al (2010) Cortical thickness is influenced by regionally specific genetic factors. Biol Psychiatry 67:493–499. doi:10.1016/j.biopsych.2009.09.032 PubMed PubMedCentral CrossRef
Roberts TPL, Heiken K, Zarnow D et al (2013) Left hemisphere diffusivity of the arcuate fasciculus: influences of autism spectrum disorder and language impairment. AJNR. doi:10.3174/ajnr.A3754
Rudie JD, Dapretto M (2013) Convergent evidence of brain overconnectivity in children with autism? Cell Rep 5:565–566. doi:10.1016/j.celrep.2013.10.043 PubMed CrossRef
Rudie JD, Brown JA, Beck-Pancer D et al (2012) Altered functional and structural brain network organization in autism. NeuroImage Clin 2:79–94. doi:10.1016/j.nicl.2012.11.006 PubMed PubMedCentral CrossRef
Schmitt JE, Lenroot RK, Wallace GL et al (2008) Identification of genetically mediated cortical networks: a multivariate study of pediatric twins and siblings. Cereb Cortex 18:1737–1747. doi:10.1093/cercor/bhm211 PubMed PubMedCentral CrossRef
Schopler E, Richler R, Renner B (1986) The Childhood Autism Rating Scale (CARS) for diagnostic screening and classification of autism. Irvington, New York
Seeley WW, Crawford RK, Zhou J et al (2009) Neurodegenerative diseases target large-scale human brain networks. Neuron 62:42–52. doi:10.1016/j.neuron.2009.03.024 PubMed PubMedCentral CrossRef
Shah A, Frith U (1983) An islet of ability in autistic children: a research note. J Child Psychol Psychiatry 24:613–620PubMed CrossRef
Sharda M, Singh NC (2012) Structural and functional networks underlying auditory processing in children with autism. In: annual meeting of society for neuroscience, New Orleans, p 122051
Sharda M, Midha R, Malik S et al (2014) Fronto-temporal connectivity is preserved during sung but not spoken word listening, across the autism spectrum. Autism Res. doi:10.1002/aur.1437 PubMed
Sled JG, Zijdenbos AP, Evans AC (1998) A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Trans Med Imaging 17:87–97. doi:10.1109/42.668698 PubMed CrossRef
Sparrow S, Balla D, Cicchetti D (1984) Vineland Adaptive Behaviour Scales Interview. American Guidance Service, Circle Pines
Spreng RN, Turner GR (2013) Structural covariance of the default network in healthy and pathological aging. J Neurosci 33:15226–15234. doi:10.1523/JNEUROSCI.2261-13.2013 PubMed PubMedCentral CrossRef
Stanfield AC, McIntosh AM, Spencer MD et al (2008) Towards a neuroanatomy of autism: a systematic review and meta-analysis of structural magnetic resonance imaging studies. Eur Psychiatry 23:289–299. doi:10.1016/j.eurpsy.2007.05.006 PubMed CrossRef
Stigler KA, McDonald BC, Anand A et al (2011) Structural and functional magnetic resonance imaging of autism spectrum disorders. Brain Res 1380:146–161. doi:10.1016/j.brainres.2010.11.076 PubMed PubMedCentral CrossRef
Sui J, Huster R, Yu Q et al (2013) Function-structure associations of the brain: evidence from multimodal connectivity and covariance studies. Neuroimage. doi:10.1016/j.neuroimage.2013.09.044
Tager-Flusberg H, Paul R, Lord C (2005) Language and communication in autism. In: Volkmar F, Paul R, Klin A, Cohen D (eds) Handbook of autism and pervasive developmental disorders, 3rd edn. Hoboken, NJ, pp 335–364
Taylor JE, Worsley KJ (2007) Detecting sparse signals in random fields, with an application to brain mapping. J Am Stat Assoc 102:913–928. doi:10.1198/016214507000000815 CrossRef
Tohka J, Zijdenbos A, Evans A (2004) Fast and robust parameter estimation for statistical partial volume models in brain MRI. Neuroimage 23:84–97. doi:10.1016/j.neuroimage.2004.05.007 PubMed CrossRef
Tost H, Bilek E, Meyer-Lindenberg A (2012) Brain connectivity in psychiatric imaging genetics. Neuroimage 62:2250–2260. doi:10.1016/j.neuroimage.2011.11.007 PubMed CrossRef
Tzourio-Mazoyer N, Landeau B, Papathanassiou D et al (2002) Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 15:273–289. doi:10.1006/nimg.2001.0978 PubMed CrossRef
Uddin LQ, Supekar K, Lynch CJ et al (2013a) Salience network-based classification and prediction of symptom severity in children with autism. JAMA psychiatry 70:869–879. doi:10.1001/jamapsychiatry.2013.104 PubMed PubMedCentral CrossRef
Uddin LQ, Supekar K, Menon V (2013b) Reconceptualizing functional brain connectivity in autism from a developmental perspective. Front Hum Neurosci 7:458. doi:10.3389/fnhum.2013.00458 PubMed PubMedCentral CrossRef
Vissers ME, Cohen MX, Geurts HM (2012) Brain connectivity and high functioning autism: a promising path of research that needs refined models, methodological convergence, and stronger behavioral links. Neurosci Biobehav Rev 36:604–625. doi:10.1016/j.neubiorev.2011.09.003 PubMed CrossRef
Wallace GL, Dankner N, Kenworthy L et al (2010) Age-related temporal and parietal cortical thinning in autism spectrum disorders. Brain 133:3745–3754. doi:10.1093/brain/awq279 PubMed PubMedCentral CrossRef
Wan CY, Marchina S, Norton A, Schlaug G (2012) Atypical hemispheric asymmetry in the arcuate fasciculus of completely nonverbal children with autism. Ann NY Acad Sci 1252:332–337. doi:10.1111/j.1749-6632.2012.06446.x PubMed PubMedCentral CrossRef
Wang AT, Lee SS, Sigman M, Dapretto M (2006) Neural basis of irony comprehension in children with autism: the role of prosody and context. Brain 129:932–943. doi:10.1093/brain/awl032 PubMed PubMedCentral CrossRef
Wechsler D (1939) The Measurement of Adult Intelligence. Williams and Witkins, BaltimoreCrossRef
Williams DL, Cherkassky VL, Mason RA et al (2013) Brain function differences in language processing in children and adults with autism. Autism Res 6:288–302. doi:10.1002/aur.1291 PubMed PubMedCentral CrossRef
Yeo BTT, Krienen FM, Sepulcre J et al (2011) The organization of the human cerebral cortex estimated by intrinsic functional connectivity. J Neurophysiol 106:1125–1165. doi:10.1152/jn.00338.2011 PubMed CrossRef
Zhang K, Sejnowski TJ (2000) A universal scaling law between gray matter and white matter of cerebral cortex. Proc Natl Acad Sci USA 97:5621–5626. doi:10.1073/pnas.090504197 PubMed PubMedCentral CrossRef
Zhang Z, Liao W, Zuo X-N et al (2011) Resting-state brain organization revealed by functional covariance networks. PLoS One 6:e28817. doi:10.1371/journal.pone.0028817 PubMed PubMedCentral CrossRef
Zielinski BA, Gennatas ED, Zhou J, Seeley WW (2010) Network-level structural covariance in the developing brain. Proc Natl Acad Sci USA 107:18191–18196. doi:10.1073/pnas.1003109107 PubMed PubMedCentral CrossRef
Zielinski BA, Anderson JS, Froehlich AL et al (2012) scMRI reveals large-scale brain network abnormalities in autism. PLoS One 7:e49172. doi:10.1371/journal.pone.0049172 PubMed PubMedCentral CrossRef
Zielinski BA, Prigge MBD, Nielsen JA et al (2014) Longitudinal changes in cortical thickness in autism and typical development. Brain. doi:10.1093/brain/awu083 PubMed PubMedCentral
Zijdenbos AP, Forghani R, Evans AC (2002) Automatic “pipeline” analysis of 3-D MRI data for clinical trials: application to multiple sclerosis. IEEE Trans Med Imaging 21:1280–1291. doi:10.1109/TMI.2002.806283 PubMed CrossRef
Zilbovicius M, Garreau B, Samson Y et al (1995) Delayed maturation of the frontal cortex in childhood autism. Am J Psychiatry 152:248–252PubMed CrossRef - 作者单位：Megha Sharda (1)
Budhachandra S. Khundrakpam (2)
Alan C. Evans (2)
Nandini C. Singh (1)
1. Department of Cognitive Neuroscience and Neuroimaging, National Brain Research Centre, NH-8, Nainwal Mode, Manesar, Gurgaon, 122051, India
2. McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada - 刊物主题：Neurosciences; Cell Biology; Neurology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1863-2661
文摘
The presence of widespread speech and language deficits is a core feature of autism spectrum disorders (ASD). These impairments have often been attributed to altered connections between brain regions. Recent developments in anatomical correlation-based approaches to map structural covariance offer an effective way of studying such connections in vivo. In this study, we employed such a structural covariance network (SCN)-based approach to investigate the integrity of anatomical networks in fronto-temporal brain regions of twenty children with ASD compared to an age and gender-matched control group of twenty-two children. Our findings reflected large-scale disruption of inter and intrahemispheric covariance in left frontal SCNs in the ASD group compared to controls, but no differences in right fronto-temporal SCNs. Interhemispheric covariance in left-seeded networks was further found to be modulated by verbal ability of the participants irrespective of autism diagnosis, suggesting that language function might be related to the strength of interhemispheric structural covariance between frontal regions. Additionally, regional cortical thickening was observed in right frontal and left posterior regions, which was predicted by decreasing symptom severity and increasing verbal ability in ASD. These findings unify reports of regional differences in cortical morphology in ASD. They also suggest that reduced left hemisphere asymmetry and increased frontal growth may not only reflect neurodevelopmental aberrations but also compensatory mechanisms.