Insistence on sameness relates to increased covariance of gray matter structure in autism spectrum disorder
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- 作者：Ian W. Eisenberg ; Gregory L. Wallace ; Lauren Kenworthy…
- 关键词：Autism ; Insistence on sameness ; Repetitive behavior ; MRI ; Structural covariance ; Subcortex
- 刊名：Molecular Autism
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：6
- 期：1
- 全文大小：1,450 KB
- 刊物主题：Neurology; Neurosciences; Neuropsychology; Molecular Medicine; Psychiatry; Pediatrics;
- 出版者：BioMed Central
- ISSN：2040-2392
文摘
Background Autism spectrum disorder (ASD) is characterized by atypical development of cortical and subcortical gray matter volume. Subcortical structural changes have been associated with restricted and repetitive behavior (RRB), a core component of ASD. Behavioral studies have identified insistence on sameness (IS) as a separable RRB dimension prominent in high-functioning ASD, though no simple brain-behavior relationship has emerged. Structural covariance, a measure of morphological coupling among brain regions using magnetic resonance imaging (MRI), has proven an informative measure of anatomical relationships in typical development and neurodevelopmental disorders. In this study, we use this measure to characterize the relationship between brain structure and IS.