Gamma Knife? radiosurgery for recurrent intracranial olfactory neuroblastoma (esthesioneuroblastoma): a case report

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• 作者：Eduard B Dinca (1)
  Matthias W Radatz (1)
  Jeremy Rowe (1)
  Andras A Kemeny (1)
  
• 刊名：Journal of Medical Case Reports
• 出版年：2012
• 出版时间：December 2012
• 年：2012
• 卷：6
• 期：1
• 全文大小：548KB
• 参考文献：1. Thompson LD: Olfactory neuroblastoma. / Head Neck Pathol 2009, 3:252-59. CrossRef
  2. Unger F, Haselsberger K, Walch C, Stammberger H, Papaefthymiou G, Unger F, Haselsberger K, Walch C, Stammberger H, Papaefthymiou G: Combined endoscopic surgery and radiosurgery as treatment modality for olfactory neuroblastoma (esthesioneuroblastoma). / Acta Neurochir (Wien) 2005, 147:595-01. CrossRef
  3. Hyams V: Tumors of the upper respiratory tract and ear. In / Atlas of Tumour Pathology. Edited by: Hyams V, Batsakis JG, Michaels L. Armed Forces Institute of Pathology, Washington D.C.; 1998:240-48.
  4. Biller HF, Lawson W, Sachdev VP, Som P: Esthesioneuroblastoma: surgical treatment without radiation. / Laryngoscope 1990, 100:1199-201. CrossRef
  5. Dulguerov P, Allal AS, Calcaterra TC: Esthesioneuroblastoma: a meta-analysis and review. / Lancet Oncol 2001, 2:683-90. CrossRef
  6. Kadish S, Goodman M, Wang CC: Olfactory neuroblastoma. A clinical analysis of 17 cases. / Cancer 1976, 37:1571-576. CrossRef
  7. Berger L, Luc R: L'esthesioneuroepitheliome olfactif. / Bull Assoc Fr Etude Cancer 1924, 13:410-21.
  8. Parsons JT, Kimsey FC, Mendenhall WM, Million RR, Cassisi NJ, Stringer SP: Radiation therapy for sinus malignancies. / Otolaryngol Clin North Am 1995, 28:1259-268.
  9. Lund VJ, Howard D, Wei W, Spittle M: Olfactory neuroblastoma: past, present, and future? / Laryngoscope 2003, 113:502-07. CrossRef
  10. McElroy EA, Buckner JC, Lewis JE: Chemotherapy for advanced esthesioneuroblastoma: the Mayo Clinic experience. / Neurosurgery 1998, 42:1023-027. CrossRef
  11. Unger F, Walch C, Stammberger H, Papaefthymiou G, Haselsberger K, Pendl G: Olfactory neuroblastoma (esthesioneuroblastoma): report of six cases treated by a novel combination of endoscopic surgery and radiosurgery. / Minim Invasive Neurosurg 2001, 44:79-4. CrossRef
  12. Walch C, Stammberger H, Anderhuber W, Unger F, Kole W, Feichtinger K: The minimally invasive approach to olfactory neuroblastoma: combined endoscopic and stereotactic treatment. / Laryngoscope 2000, 110:635-40. CrossRef
  
• 作者单位：Eduard B Dinca (1)
  Matthias W Radatz (1)
  Jeremy Rowe (1)
  Andras A Kemeny (1)
  
  1. The National Centre for Stereotactic Radiosurgery, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK
  

文摘

Background We report the use of salvage radiosurgery to manage an aggressive olfactory neuroblastoma (esthesioneuroblastoma) with multiple recurrences and intracranial extension. Case presentation A 43-year-old Caucasian woman presented 11 years ago with progressive nasal blockage and headaches. A necrotic polyp originating in her left middle meatus and extending to the ethmoid air cells and cribriform plate (Kadish stage C) was radically resected via a craniofacial approach. Four years later, a local recurrence extending into her left cavernous sinus was identified and deemed inoperable. She received vincristine, ifosfamide, doxorubicin and etoposide chemotherapy (with minimal benefit) and external beam radiotherapy (60Gy in 30 fractions) to her skull base. Two years later, tumour extension in her left neck was treated with radical radiotherapy. She developed visual disturbances in her left eye, which progressed to blindness in the next two years. Having exhausted chemoradiotherapy, the left cavernous sinus esthesioneuroblastoma was treated with Gamma Knife? radiosurgery 2?years ago (20Gy at 50% isodose, tumour volume 7.5cm3). At one year, there was dramatic reduction in the tumour and no new symptoms; however, there were new tumour foci (in her left frontal lobe and above her right orbital apex). These were again treated with radiosurgery (20Gy at 50% isodose, total tumour volume 0.67cm3). Repeat imaging at six months showed no further disease progression. Conclusion Whilst rare, olfactory neuroblastoma (esthesioneuroblastoma) can present management challenges and Gamma Knife? radiosurgery may prove a useful strategy in controlling intracranial spread.