Gastrointestinal Safety of Aspirin for a High-Dose, Multiple-Day Treatment Regimen: A Meta-Analysis of Three Randomized Controlled Trials

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• 作者：Samantha Forder ; Michael Voelker ; Angel Lanas
• 刊名：Drugs in R&D
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：16
• 期：3
• 页码：263-269
• 全文大小：407 KB
• 刊物主题：Pharmacotherapy; Pharmacology/Toxicology; Internal Medicine;
• 出版者：Springer International Publishing
• ISSN：1179-6901
• 卷排序：16

文摘

Background and AimAspirin is a commonly used over-the-counter (OTC) agent for the symptomatic treatment of acute pain, fever, or the common cold, but data regarding safety in this context are limited. In order to characterize the safety of aspirin beyond single-dose or long-term use data, we conducted a meta-analysis of multiple-dose, multiple-day studies of OTC aspirin at a label-approved dosage.