Quantitative spectral analysis of vigilance EEG in patients with obstructive sleep apnoea syndrome

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• 作者：Athanasios G. Xiromeritis (1)
  Apostolia A. Hatziefthimiou (2)
  Georgios M. Hadjigeorgiou (3)
  Konstantinos I. Gourgoulianis (4)
  Dimitra N. Anagnostopoulou (1)
  Nikiforos V. Angelopoulos (1)
  
• 关键词：Cerebral hypoxemia ; Continuous positive airway pressure ; FFT ; Obstructive sleep apnoea ; Quantitative EEG ; Spectral analysis
• 刊名：Sleep and Breathing
• 出版年：2011
• 出版时间：January 2011
• 年：2011
• 卷：15
• 期：1
• 页码：121-128
• 全文大小：141KB
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• 作者单位：Athanasios G. Xiromeritis (1)
  Apostolia A. Hatziefthimiou (2)
  Georgios M. Hadjigeorgiou (3)
  Konstantinos I. Gourgoulianis (4)
  Dimitra N. Anagnostopoulou (1)
  Nikiforos V. Angelopoulos (1)
  
  1. Department of Psychiatry, School of Medicine, University of Thessaly, University Hospital of Larissa, GR-411 10, Larissa, Greece
  2. Department of Physiology, School of Medicine, University of Thessaly, University Hospital of Larissa, GR-411 10, Larissa, Greece
  3. Department of Neurology, School of Medicine, University of Thessaly, University Hospital of Larissa, GR-411 10, Larissa, Greece
  4. Department of Respiratory Medicine, School of Medicine, University of Thessaly, University Hospital of Larissa, GR-411 10, Larissa, Greece
  

文摘

Introduction Sleep disruption and blood gas abnormalities, observed in patients with obstructive sleep apnoea (OSA) syndrome, prevent sleep-related restorative processes and induce chemical or structural central nervous system cellular injury. The aim of the study was to determine electroencephalogram (EEG) alterations related to the severity of OSA in patients with OSAS and the effect of the nasal continuous positive air pressure (nCPAP) treatment. Materials and methods Polysomnography and vigilant EEGs were performed in subjects with possible OSA. The mean relative power was calculated for delta, theta, alpha and beta frequency bands. Thirty subjects without and 131 with OSA participated in this study. In 29 male patients with severe OSA, quantitative EEGs were re-evaluated after 6?months of CPAP treatment. Results Compared to subjects without OSA, patients with severe OSA showed an increase in relative theta and delta power (occipital, temporal and parietal areas). Six months of nCPAP treatment improved daytime sleepiness of OSA patients. EEG demonstrated a decrease in alpha (frontal, central and temporal areas) and theta (frontal areas) relative power. However, beta relative power was increased mainly in central, and delta relative power, in all brain areas. Discussion In conclusion, EEG slowing was observed in OSA patients. CPAP treatment improved daytime sleepiness of OSA patients in contrast to the alterations in alpha (decreased) and delta (increased) relative power suggesting a possible persistent brain dysfunction.