Serostatus of Epstein–Barr virus in Iranian MS patients

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• 作者：Sajad Karampoor ; Hamid Zahednasab ; Angila Ataei Pirkouh…
• 关键词：Multiple sclerosis ; Epstein–Barr virus ; Serology ; Environmental factors ; Immunoglobulin ; Infection
• 刊名：Acta Neurologica Belgica
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：116
• 期：1
• 页码：43-46
• 全文大小：326 KB
• 参考文献：1.Ramagopalan SV, Dobson R, Meier UC, Giovannoni G (2010) Multiple sclerosis: risk factors, prodromes, and potential causal pathways. Lancet Neurol 9(7):727–739CrossRef PubMed
  2.Etemadifar M, Abtahi S-H, Akbari M, Murray RT, Ramagopalan SV, Fereidan-Esfahani M (2013) Multiple sclerosis in Isfahan, Iran: an update. Mult Scler Houndmills Basingstoke Engl 20(8):1145–1147CrossRef
  3.Khaki M, Ghazavi A, Ghasami K, Rafiei M, Payani M-A, Ghaznavi-Rad E et al (2011) Evaluation of viral antibodies in Iranian multiple sclerosis patients. Neurosci Riyadh Saudi Arab 16(3):224–228
  4.McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD et al (2001) Recommended diagnostic criteria for multiple sclerosis: guidelines from the International panel on the diagnosis of multiple sclerosis. Ann Neurol 50(1):121–127CrossRef PubMed
  5.Polman CH, Reingold SC, Edan G, Filippi M, Hartung H-P, Kappos L et al (2005) Diagnostic criteria for multiple sclerosis: 2005 revisions to the ‘McDonald Criteria’. Ann Neurol 58(6):840–846CrossRef PubMed
  6.Kurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33(11):1444–1452CrossRef PubMed
  7.Levin LI, Munger KL, O’Reilly EJ, Falk KI, Ascherio A (2010) Primary infection with the Epstein–Barr virus and risk of multiple sclerosis. Ann Neurol 67(6):824–830PubMedCentral PubMed
  8.Levin LI, Munger KL, Rubertone MV, Peck CA, Lennette ET, Spiegelman D et al (2005) Temporal relationship between elevation of Epstein–Barr virus antibody titers and initial onset of neurological symptoms in multiple sclerosis. JAMA 293(20):2496–2500CrossRef PubMed
  9.Ramroodi N, Niazi AA, Sanadgol N, Ganjali Z, Sarabandi V (2013) Evaluation of reactive Epstein–Barr Virus (EBV) in Iranian patient with different subtypes of multiple sclerosis (MS). Braz J Infect Dis Off Publ Braz Soc Infect Dis 17(2):156–163
  10.De Paschale M, Clerici P (2012) Serological diagnosis of Epstein–Barr virus infection: problems and solutions. World J Virol 1(1):31–43PubMedCentral CrossRef PubMed
  11.Farrell RA, Antony D, Wall GR, Clark DA, Fisniku L, Swanton J et al (2009) Humoral immune response to EBV in multiple sclerosis is associated with disease activity on MRI. Neurology 73(1):32–38PubMedCentral CrossRef PubMed
  12.Etemadifar M, Izadi S, Nikseresht A, Sharifian M, Sahraian MA, Nasr Z (2014) Estimated prevalence and incidence of multiple sclerosis in Iran. Eur Neurol 72(5–6):370–374CrossRef PubMed
  
• 作者单位：Sajad Karampoor (1)
  Hamid Zahednasab (2)
  Angila Ataei Pirkouh (3)
  Seyed Hamid Reza Monavari (3)
  Sreeram Ramagopalan (4)
  Hossein Keyvani (3)
  
  1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Hemmat Highway, Tehran, Iran
  2. Institute of Biochemistry and Biophysics, The University of Tehran, Tehran, Iran
  3. Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  4. Medical Research Council Functional Genomics Unit and Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK
  
• 刊物主题：Neurosciences; Neurology; Neuroradiology; Medicine/Public Health, general;
• 出版者：Springer Milan
• ISSN：2240-2993

文摘

Multiple sclerosis (MS) is a common, complex disorder. Associations of MS with Epstein–Barr virus (EBV) infection in Caucasian populations are well documented. However, in the Iranian population, previous studies have been conflicting. Sixty patients with MS and 50 healthy controls were tested for anti-EBV antibodies using chemiluminescent assays. All MS patients to be seropositive for EBV as compared to 82 % of controls (p = 0.0006). A strong, significant association of MS with EBV infection was documented, similar to studies in first world populations. Future studies should investigate the temporal sequence of infection to try to understand the cause of the recent increase in MS risk in Iran.