Novel Cu(II) complexes of bithiazole: structure and biological study

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• 作者：Anita Abedi ; Zohreh Mehri-Lighvan ; Mina Yasan…
• 关键词：Copper complex ; Bithiazole ; Molecular structure ; DNA interaction ; BSA interaction
• 刊名：Journal of the Iranian Chemical Society
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：14
• 期：2
• 页码：491-502
• 全文大小：
• 刊物主题：Analytical Chemistry; Inorganic Chemistry; Physical Chemistry; Biochemistry, general; Organic Chemistry;
• 出版者：Springer Berlin Heidelberg
• ISSN：1735-2428
• 卷排序：14

文摘

The reaction of copper(II) bromide with 2,2′-dimethyl-4,4′-bithiazole (dm4bt) affords a dimer complex, [{CuBr(dm4bt)}₂(µ-Br)₂] (1), in CH₃OH/CH₃CN; and a monomer complex, [Cu(dm4bt)Br₂(DMSO)] (2), in DMSO. Monomer copper(II) complex [Cu(4bt)Br₂(DMSO)] (3) also resulted from the treatment of the copper salt with 4,4′-bithiazole (4bt) in DMSO. The complexes were characterized by elemental analysis, IR, UV and X-ray crystallography. The interaction of monomeric complexes 2 and 3 with calf thymus DNA (CT DNA) has been explored by using absorption, emission and thermal denaturation, where they exhibit high interaction ability with CT DNA, with intrinsic binding constants K_b of 1.58 × 105 and 1.24 × 105 M−1 at 298 K, for complexes 2 and 3, respectively. Furthermore, the intermolecular interaction between the mentioned copper complexes and bovine serum albumin (BSA) under imitated physiological conditions was investigated using UV–Vis and fluorescence. Tryptophan-quenching experiment illustrated that both complexes strongly bind BSA, with dynamic quenching constants of about 1 × 105 M−1 s−1 at 298 K, and a single class of binding site for the complexes on BSA.