Associations between thyroid hormones and serum metabolite profiles in an euthyroid population

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• 作者：Carolin Jourdan (1)
  Jakob Linseisen (1)
  Christa Meisinger (1) (2)
  Ann-Kristin Petersen (3)
  Christian Gieger (3)
  Rajesh Rawal (3)
  Thomas Illig (4) (5)
  Margit Heier (2)
  Annette Peters (2) (4)
  Henri Wallaschofski (6)
  Matthias Nauck (6)
  Gabi Kastenmüller (7)
  Karsten Suhre (7) (8)
  Cornelia Prehn (9)
  Jerzy Adamski (10) (9)
  Wolfgang Koenig (11)
  Michael Roden (12)
  H-Erich Wichmann (1) (13) (14)
  Henry V?lzke (15)
  
• 关键词：Targeted metabolomics ; Serum metabolites ; Free thyroxine ; Thyrotropin ; Thyroid hormones ; Epidemiology
• 刊名：Metabolomics
• 出版年：2014
• 出版时间：February 2014
• 年：2014
• 卷：10
• 期：1
• 页码：152-164
• 全文大小：344 KB
• 作者单位：Carolin Jourdan (1)
  Jakob Linseisen (1)
  Christa Meisinger (1) (2)
  Ann-Kristin Petersen (3)
  Christian Gieger (3)
  Rajesh Rawal (3)
  Thomas Illig (4) (5)
  Margit Heier (2)
  Annette Peters (2) (4)
  Henri Wallaschofski (6)
  Matthias Nauck (6)
  Gabi Kastenmüller (7)
  Karsten Suhre (7) (8)
  Cornelia Prehn (9)
  Jerzy Adamski (10) (9)
  Wolfgang Koenig (11)
  Michael Roden (12)
  H-Erich Wichmann (1) (13) (14)
  Henry V?lzke (15)
  
  1. Institute of Epidemiology I, Helmholtz Zentrum München, German Research Centre for Environmental Health (HMGU), Ingolst?dter Landstra?e 1, 85746, Neuherberg, Germany
  2. Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany
  3. Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany
  4. Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany
  5. Hannover Unified Biobank, Hannover Medical School, Hannover, Germany
  6. Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany
  7. Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Neuherberg, Germany
  8. Department of Physiology and Biophysics, Weill Cornell Medical College, Education City, Doha, Qatar
  9. Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, Neuherberg, Germany
  10. Institute of Experimental Genetics, Life and Food Science Center Weihenstephan, Technische Universit?t München, Freising-Weihenstephan, Germany
  11. Department of Internal Medicine II-Cardiology, University of Ulm, Medical Center, Ulm, Germany
  12. Institute for Clinical Diabetology, German Diabetes Center, Düsseldorf, Germany
  13. Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universit?t München, Neuherberg, Germany
  14. Klinikum Gro?hadern, Munich, Germany
  15. Institute for Community Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany
  
• ISSN：1573-3890

文摘

The aim was to characterise associations between circulating thyroid hormones—free thyroxine (FT4) and thyrotropin (TSH)—and the metabolite profiles in serum samples from participants of the German population-based KORA F4 study. Analyses were based on the metabolite profile of 1463 euthyroid subjects. In serum samples, obtained after overnight fasting (?), 151 different metabolites were quantified in a targeted approach including amino acids, acylcarnitines (ACs), and phosphatidylcholines (PCs). Associations between metabolites and thyroid hormone concentrations were analysed using adjusted linear regression models. To draw conclusions on thyroid hormone related pathways, intra-class metabolite ratios were additionally explored. We discovered 154 significant associations (Bonferroni p?<?1.75?×?10?4) between FT4 and various metabolites and metabolite ratios belonging to AC and PC groups. Significant associations with TSH were lacking. High FT4 levels were associated with increased concentrations of many ACs and various sums of ACs of different chain length, and the ratio of C2 by C0. The inverse associations observed between FT4 and many serum PCs reflected the general decrease in PC concentrations. Similar results were found in subgroup analyses, e.g., in weight-stable subjects or in obese subjects. Further, results were independent of different parameters for liver or kidney function, or inflammation, which supports the notion of an independent FT4 effect. In fasting euthyroid adults, higher serum FT4 levels are associated with increased serum AC concentrations and an increased ratio of C2 by C0 which is indicative of an overall enhanced fatty acyl mitochondrial transport and β-oxidation of fatty acids.