A fragmented form of annexin A1 is secreted from C2C12 myotubes by electric pulse-induced contraction

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• 作者：Naoko Goto-Inoue ; Kotaro Tamura ; Fumika Motai…
• 关键词：Annexin A1 ; C2C12 myotubes ; Contraction ; Secretion
• 刊名：Molecular and Cellular Biochemistry
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：411
• 期：1-2
• 页码：173-180
• 全文大小：759 KB
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• 作者单位：Naoko Goto-Inoue (1)
  Kotaro Tamura (2)
  Fumika Motai (2)
  Miyuki Ito (2)
  Kaede Miyata (2)
  Yasuko Manabe (2)
  Nobuharu L. Fujii (2)
  
  1. Department of Marine Science and Resources, College of Bioresource Sciences, Nihon University, Kameino 1866, Fujisawa, Kanagawa, 252-0880, Japan
  2. Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, 1-1, Minami-Osawa, Hachioji, Tokyo, 192-0397, Japan
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Medical Biochemistry
  Oncology
  Cardiology
  
• 出版者：Springer Netherlands
• ISSN：1573-4919

文摘

The main function of annexin A1 (ANXA1), a member of the annexin superfamily, is to bind to cellular membranes in a Ca2+-dependent manner. In skeletal muscle, ANXA1 is thought to be involved in the repair of damaged membrane tissue and in the migration of muscle cells. We hypothesized that ANXA1 is one of the myokines secreted during muscle contractions to accelerate the repair of cell damage after contraction. Here we performed cell contractions by electric pulse stimulation; the results revealed that a fragmented form of ANXA1 was cleaved by calpain and selectively secreted from skeletal muscle cells by contraction. We therefore realized that muscle-contraction-induced calpain-dependent ANXA1 fragmentation has a wound-healing effect on damaged cells. This suggested that not the intact form but rather fragmented ANXA1 is a contraction-induced myokine. Keywords Annexin A1 C2C12 myotubes Contraction Secretion