Diagnostic Accuracy of Fecal Elastase 1 Assay in Patients with Pancreatic Maldigestion or Intestinal Malabsorption

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• 作者：A. Carroccio ; F. Verghi ; B. Santini ; V. Lucidi ; G. Iacono ; F. Cavataio ; M. Soresi ; N. Ansaldi ; M. Castro and G. Montalto
• 关键词：fecal elastase ; 1 ; fecal chymotrypsin ; steatorrhea ; cystic fibrosis ; celiac disease ; intestinal giardiasis ; pancreatic insufficiency ; malabsorption syndrome ; sensitivity ; specificity
• 刊名：Digestive Diseases and Sciences
• 出版年：2001
• 出版时间：2001
• 年：2001
• 卷：46
• 期：6
• 页码：1335-1342
• 全文大小：78 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gastroenterology
  Hepatology
  Oncology
  Transplant Surgery
  Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-2568

文摘

Several reports have indicated that fecal elastase-1 (EL-1) determination is a new, sensitive, and specific noninvasive pancreatic function test; however, very few patients with malabsorption due to small intestine diseases have been included in the previous studies. The aim of the study was to compare the diagnostic accuracy of fecal EL-1 and fecal chymotrypsin (FCT) in distinguishing between pancreatic maldigestion and intestinal malabsorption. Three groups of subjects were studied: group A included 49 patients with known cystic fibrosis (25 males, median age 5 years); group B included 43 subjects with various small intestine diseases (17 males, median age 6 years); and group C included 45 children without any history of gastrointestinal disease (22 males, median age 5 years). In all patients, stools were collected for 72 h on a standard diet and fecal EL-1, FCT, and steatocrit tests were performed. Both EL-1 and FCT were below normal limits in all CF patients with pancreatic maldigestion not treated with pancreatic enzyme (100% sensitivity for both assays); El-1, but not FCT, was also below normal in all the CF patients with pancreatic maldigestion treated with pancreatic extracts. Both EL-1 and FCT values in the CF group were significantly lower than in subjects with various small intestinal diseases and in children without any history of gastrointestinal disease (P