Prevalence and predictors of Cervical Intraepithelial Neoplasia among HIV infected women at Bugando Medical Centre, Mwanza-Tanzania
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- 作者：Lilian Kafuruki (1)
Peter Fabian Rambau (2)
Anthony Massinde (1)
Nestory Masalu (3) - 关键词：Cervical intraepithelial Neoplasia ; HIV ; Mwanza
- 刊名：Infectious Agents and Cancer
- 出版年：2013
- 出版时间：December 2013
- 年：2013
- 卷：8
- 期：1
- 全文大小：182 KB
- 参考文献：1. Parkin DM, Freddie B, Ferlay J, Paola P: Global Cancer Statistics, 2002. / CA Cancer J Clin 2005, 55:74-0822. CrossRef
2. Gopal KS, Romuladus EA, Mohammad S: Global Inequalities in Cervical Cancer Incidence and Mortality are Limited to Deprivation, Low Socioeconomic Status, and Human Development. / Int J MCH and AIDS 2012,1(1):17-0.
3. Keita N, Clifford GM, Koulibaly M, / et al.: HPV infection in women with and without cervical cancer in Conakry, Guinea. / Br J Cancer 2009,101(1):202-20. CrossRef
4. Lisa MP, Mkuchu J, Ngoma T, / et al.: Evidence for need of Education Programs for cervical cancer screening in Rural Tanzania. / J Cancer Educ 2010,25(2):153-59. CrossRef
5. / WHO/ICO information Center on HPV and cervical cancer (HPV information center); Human Papillomavirus and related cancer in World Summary Report. 2010.
6. Parham GP, Sahasrabuddhe VV, Mwanahamuntu MH, / et al.: Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV infected women in Lusaka, Zambia. / Gynecol Oncol 2006,103(3):1017-022. CrossRef
7. Franceschi S, Jaffe H: Cervical Cancer screening of women living with HIV infection a must in era of antiretroviral therapy. / Clin Infect Dis 2007,45(4):510-13. CrossRef
8. Lim FK: Management of Pre malignant lesions of the cervix. / Ann Academic Med Singapore 2002, 31:557-64.
9. / Comprehensive cervical control: a guide to essential practice. Geneva: WHO; 2006.
10. Waggoner SE: Cervical cancer. / Lancet 2003,361(9376):2217-225. CrossRef
11. Divya H, Harish S, Prassana KS: Diagnostic value of VIA comparing with conventional papanicolau smear in the detection of colposcopic biopsy proved CIN. / Natl J Obstet Gynecol 2011,6(1):7-2.
12. Ghaemmaghami F, Modarres GM, Marjani M, / et al.: Assessment of Visual Inspection with Acetic acid (VIA) as a screening test for cervical neoplasia in comparison with cytologic screening. / Acta Media Iranica 2003,41(4):p248-p253.
13. University of Zimbabwe/JHPIEGO Cervical Cancer Project: Visual inspection with acetic for cervical cancer screening; test qualities in a primary care setting. / Lancet 1999,353(9156):869-73. CrossRef
14. Kapiga SH, Msamanga GI, Spiegelman D, Mwakyoma H, Fawzi WW: Risk factors for cervical squamous intraepithelial lesions among HIV-1 seropositive women in Dar es salaam. / Tanzania Int J Gynecol Obstet 1999,67(2):87-4. CrossRef
15. Mwakigonja A, Liset MT, Mwakyoma H, / et al.: Cervical Cytological Changes in HIV infected patients attending care and treatments clinic at Muhimbili National Hospital, Dar-Es-Salaam Tanzania. / Infect Agent Cancer 2012,7(1):3-. CrossRef
16. Mayaud P, Gill DK, Weiss HA: The interrelation of HIV, cervical human papillomavirus and neoplasia among antenatal clinic attendee’s in Tanzania. / Sex Transm Infect 2001,77(4):248-58. CrossRef
17. Obure J, Olola O, Masenga G, / et al.: Prevalence and severity of cervical squamous intraepithelial lesion. / Tanzania J Health Res 2009,11(4):163-69.
18. PEPFAR: Tanzania Operational Plan report FY 2011. / FACTS Info 3.8.3.30:1-42.
19. Balandya BS, Pembe AB, Mwakyoma HA: Cervical premalignant lesion in HIV infected women attending Care and Treatment Centre in Tertiary hospital Dar es Salaam. / Tanzania East Africa J Public Health 2011,8(3):185-89.
20. Miotti PG, Dallabetta GA, Daniel RW: Cervical abnormalities, human papilommavirus, and human immunodeficiency virus infections in women in Malawi. / J Infect Dis 1996,173(3):714-17. CrossRef
21. Mbakop A, Zekeng L, Mbassi JR: Cytologic aspect of cervical smear in optic microscopy in HIV seropositive women in Younde Cameroon(Central Africa). / Arch Anatomy Cytology Pathology 1996,44(56):250-53.
22. Ramogola-Masire D, de Clerk R, Monare B: Cervical cancer prevention in HIV infected Women using ' See and Treat-Approach in Botswana. / J Acquire Immune Defic Syndrome 2012,59(3):308-13. CrossRef
23. Hawes SE, Critchlow CW, Sow PS, Toure P, N’Doye I, Diop A, / et al.: Incidence of high-grade squamous intraepithelial lesions in Senegalese women with and without human immunodeficiency virus type 1 (HIV-1) and HIV-2. / J Natl Canc Inst 2006, 98:100-09. CrossRef
24. De Vuyst H, Claeys P, Njiru S, / et al.: Comparison of papanicolau smear, Visual Inspection with Acetic acid Human papillomavirus DNA PCR testing and Cervicography International. / J Gynecol Obstet 2005, 89:120-26.
25. Matasha E, Ntembela T, Mayaud P, / et al.: Sexual reproductive health among primary and secondary school pupils in Mwanza Tanzania; Need for intervention. / AIDS Care 1998, 10:571-82. CrossRef
26. Dames DN, Cammile R, Andrea G: The prevalence of cervical cytology abnormalities and human papillomavirus in women infected with the Human Immunodeficiency Virus. / Infect Agents Cancer 2009,4(1):S1-S8. CrossRef
27. Kreiss JK, Kiviat NB, Plummer FA, / et al.: Human immunodeficiency virus, human papillomavirus and cervical intraepithelial neoplasia in Nairobi prostitute. / Sex Transm Dis 1992, 19:54-9. CrossRef
28. Smith JS, Green J, Peto J, / et al.: Cervical cancer and use of hormonal contraceptives: a systematic review. / Lancet 2003,361(9364):1159-167. CrossRef
29. Smith JS, Bosset L, Munoz N, / et al.: Chlamydia trachomatis and invasive cervical cancer a pooled analysis of the AIRC multicentric case control study. / Int J Cancer 2004,111(3):431-39. CrossRef
30. Munoz N, Castellsague X, Gonzalez A, / et al.: Chapter 1, HPV in the etiology of human cancer. / Vaccine 2006,24(3):1-0. CrossRef
31. Massad S, Katherine R, Kathryn A, / et al.: Prevalence and Predictors of squamous cell abnormalities in Papanicolau smear from Women Infected With HIV 1. / J Acquir Immune Defic Syndr 1999,21(1):33-1. CrossRef - 作者单位：Lilian Kafuruki (1)
Peter Fabian Rambau (2)
Anthony Massinde (1)
Nestory Masalu (3)
1. Department of Obstetrics and Gynecology, Bugando Medical Centre, Box 1370, Mwanza, Tanzania
2. Department of Pathology, Catholic University of Health Sciences and Allied Sciences (CUHAS-Bugando), Box 1464, Mwanza, Tanzania
3. Department of Oncology, Bugando Medical Centre, Box 1370, Mwanza, Tanzania - ISSN：1750-9378
文摘
Introduction Cancer of the cervix rank the second most common cause of cancer related deaths among women in Sub-Saharan Africa. It is estimated that 529, 409 new cases are diagnosed annually with a mortality rate approaching 274,883 per year. Cervical Intraepithelial Neoplasia (CIN) precedes almost all cervical cancers. The incidence rate of CIN among HIV infected women is five times higher as compared to the rate in HIV negative women. The screening for cervical dysplasia and an appropriate management in women with CIN are effective methods for preventing cervical cancer. This study was done to determine the prevalence and predictors of CIN among a HIV infected women attending Care and Treatment centre (CTC) at Bugando Medical Centre (BMC). Methods A cross sectional survey was undertaken among HIV infected women aged 18?years and above attending at BMC CTC clinic between February and March 2013. Visual Inspection with Acetic acid (VIA) was used as the screening method for detection of CIN. Socio-demographic, reproductive and clinical information was obtained from participants and the blood was collected for CD4 lymphocyte count. Cervical punch biopsy for histological examination was performed for those who had VIA positive test. Data were entered and analyzed using STATA Version 12.0 soft ware. Results A total number of 95 (26.8%) participants had positive VIA test among three hundred and fifty-five (355) HIV infected women. Histology results showed; 4(4.2%) were normal, 26 (27.4%) had an inflammatory lesion, 58(61.1%) had CIN and 7(7.3%) had invasive cervical cancer. CIN was found to be associated with a history of multiple sexual partners (P<0.001), a history of genital warts (P<0.001), and a history of STI (P = 0.010). Conclusion The Cervical Intraepithelial Neoplasia is a problem among HIV infected women. A history of multiple sexual partners, a history of genital warts, a history STI and a low baseline CD4 T lymphocyte were significant predictors for CIN. Screening for Cervical Intraepithelial Neoplasia is recommended for all women with HIV.