Direct Oral Anticoagulants: An Overview for the Interventional Radiologist

详细信息    查看全文

• 作者：Pradesh Kumar ; Rajeev Ravi ; Gaurav Sundar…
• 关键词：Direct oral anticoagulants ; Periprocedural ; Anticoagulation ; Bleeding
• 刊名：CardioVascular and Interventional Radiology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：40
• 期：3
• 页码：321-330
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Imaging / Radiology; Cardiology; Nuclear Medicine; Ultrasound;
• 出版者：Springer US
• ISSN：1432-086X
• 卷排序：40

文摘

The direct oral anticoagulants (DOACs) have emerged as a good alternative for the treatment of thromboembolic diseases, and their use in clinical practice is increasing rapidly. The DOACs act by blocking the activity of one single step in the coagulation cascade. These drugs act downstream in the common pathway of the coagulation cascade by directly antagonising the action of thrombin or factor Xa. The development of DOACs represents a paradigm shift from the oral vitamin K antagonists such as warfarin. This article aims to describe the properties of the currently available DOACs including pharmacology and dosing. We also address the strategies for periprocedural management and reversal of anticoagulation of patients treated with these agents.