Therapeutic cyclic lipopeptides mining from microbes: latest strides and hurdles

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• 作者：Seema Patel ; Shadab Ahmed ; J. Satya Eswari
• 关键词：Cyclic lipopeptides ; Non ; ribosomal peptide synthetase ; Daptomycin ; Surfactin ; Vaccine adjuvant
• 刊名：World Journal of Microbiology & Biotechnology
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：31
• 期：8
• 页码：1177-1193
• 全文大小：2,114 KB
• 参考文献：Ajesh K, Sudarslal S, Arunan C, Sreejith K (2013) Kannurin, a novel lipopeptide from Bacillus cereus strain AK1: isolation, structural evaluation and antifungal activities. J Appl Microbiol 115:1287鈥?296. doi:10.鈥?111/鈥媕am.鈥?2324
  Aktuganov G, Jokela J, Kivel盲 H et al (2014) Isolation and identification of cyclic lipopeptides from Paenibacillus ehimensis, strain IB-X-b. J Chromatogr B Analyt Technol Biomed Life Sci 973C:9鈥?6. doi:10.鈥?016/鈥媕.鈥媕chromb.鈥?014.鈥?9.鈥?42
  Aleti G, Sessitsch A, Brader G (2015) Genome mining: prediction of lipopeptides and polyketides from Bacillus and related Firmicutes. Comput Struct Biotechnol J 13:192鈥?03. doi:10.鈥?016/鈥媕.鈥媍sbj.鈥?015.鈥?3.鈥?03
  Alexander DC, Rock J, He X et al (2010) Development of a genetic system for combinatorial biosynthesis of lipopeptides in Streptomyces fradiae and heterologous expression of the A54145 biosynthesis gene cluster. Appl Environ Microbiol 76:6877鈥?887. doi:10.鈥?128/鈥婣EM.鈥?1248-10
  Alexander DC, Rock J, Gu J-Q et al (2011) Production of novel lipopeptide antibiotics related to A54145 by Streptomyces fradiae mutants blocked in biosynthesis of modified amino acids and assignment of lptJ, lptK and lptL gene functions. J Antibiot (Tokyo) 64:79鈥?7. doi:10.鈥?038/鈥媕a.鈥?010.鈥?38
  Ali S, Hameed S, Imran A et al (2014) Genetic, physiological and biochemical characterization of Bacillus sp. strain RMB7 exhibiting plant growth promoting and broad spectrum antifungal activities. Microb Cell Fact 13:144. doi:10.鈥?186/鈥媠12934-014-0144-x
  Angelini TE, Roper M, Kolter R et al (2009) Bacillus subtilis spreads by surfing on waves of surfactant. Proc Natl Acad Sci USA 106:18109鈥?8113. doi:10.鈥?073/鈥媝nas.鈥?905890106
  Aranda FJ, Teruel JA, Ortiz A (2005) Further aspects on the hemolytic activity of the antibiotic lipopeptide iturin A. Biochim Biophys Acta 1713:51鈥?6. doi:10.鈥?016/鈥媕.鈥媌bamem.鈥?005.鈥?5.鈥?03
  Arnold RS, Thom KA, Sharma S et al (2011) Emergence of Klebsiella pneumoniae carbapenemase-producing bacteria. South Med J 104:40鈥?5. doi:10.鈥?097/鈥婼MJ.鈥?b013e3181fd7d5a鈥?/span>
  Bak F, Bonnichsen L, J酶rgensen NOG et al (2014) The biosurfactant viscosin transiently stimulates n-hexadecane mineralization by a bacterial consortium. Appl Microbiol Biotechnol. doi:10.鈥?007/鈥媠00253-014-6054-3
  Baltz RH (2014) Combinatorial biosynthesis of cyclic lipopeptide antibiotics: a model for synthetic biology to accelerate the evolution of secondary metabolite biosynthetic pathways. ACS Synth Biol 3:748鈥?58. doi:10.鈥?021/鈥媠b3000673
  Baltz RH, Brian P, Miao V, Wrigley SK (2006) Combinatorial biosynthesis of lipopeptide antibiotics in Streptomyces roseosporus. J Ind Microbiol Biotechnol 33:66鈥?4. doi:10.鈥?007/鈥媠10295-005-0030-y
  Bassetti M, Cadeo B, Villa G et al (2014) Current antibiotic management of prosthetic joint infections in Italy: the 鈥淯dine strategy鈥? J Antimicrob Chemother 69(Suppl 1):i41鈥搃45. doi:10.鈥?093/鈥媕ac/鈥媎ku251
  Baumgart F, Kluge B, Ullrich C et al (1991) Identification of amino acid substitutions in the lipopeptide surfactin using 2D NMR spectroscopy. Biochem Biophys Res Commun 177:998鈥?005
  Beiras-Fernandez A, Vogt F, Sodian R, Weis F (2010) Daptomycin: a novel lipopeptide antibiotic against Gram-positive pathogens. Infect Drug Resist 3:95鈥?01. doi:10.鈥?147/鈥婭DR.鈥婼6961
  BenMohamed L, Wechsler SL, Nesburn AB (2002) Lipopeptide vaccines鈥搚esterday, today, and tomorrow. Lancet Infect Dis 2:425鈥?31
  Bland CM, Bookstaver PB, Lu ZK et al (2014) Musculoskeletal safety outcomes of patients receiving daptomycin with HMG-CoA reductase inhibitors. Antimicrob Agents Chemother 58:5726鈥?731. doi:10.鈥?128/鈥婣AC.鈥?2910-14
  Chan Tompkins NH, Harnicar SJ (2008) Prescribing trends with daptomycin (cubicin) for the treatment of gram-positive infections. P T 33:282鈥?88
  Chen Y-F, Sun T-L, Sun Y, Huang HW (2014) Interaction of daptomycin with lipid bilayers: a lipid extracting effect. Biochemistry 53:5384鈥?392. doi:10.鈥?021/鈥媌i500779g
  Chooklin CS, Maneerat S, Saimmai A (2014) Utilization of banana peel as a novel substrate for biosurfactant production by Halobacteriaceae archaeon AS65. Appl Biochem Biotechnol 173:624鈥?45. doi:10.鈥?007/鈥媠12010-014-0870-x
  Claeys KC, Fiorvento AD, Rybak MJ (2014) A review of novel combinations of colistin and lipopeptide or glycopeptide antibiotics for the treatment of multidrug-resistant Acinetobacter baumannii. Infect Dis Ther. doi:10.鈥?007/鈥媠40121-014-0051-9
  Cochrane SA, Vederas JC (2014) Lipopeptides from Bacillus and Paenibacillus spp.: a gold mine of antibiotic candidates. Med Res Rev. doi:10.鈥?002/鈥媘ed.鈥?1321
  Cochrane SA, Findlay B, Vederas JC, Ratemi ES (2014) Key residues in octyl-tridecaptin A1 analogues linked to stable secondary structures in the membrane. ChemBioChem 15:1295鈥?299. doi:10.鈥?002/鈥媍bic.鈥?01402024
  Curran WV, Leese RA, Jarolmen H et al (2007) Semisynthetic approaches to laspartomycin analogues. J Nat Prod 70:447鈥?50. doi:10.鈥?021/鈥媙p068062b
  Das N, Chandran P (2011) Microbial degradation of petroleum hydrocarbon contaminants: an overview. Biotechnol Res Int 2011:941810. doi:10.鈥?061/鈥?011/鈥?41810
  De Brucker K, Cammue BPA, Thevissen K (2011) Apoptosis-inducing antifungal peptides and proteins. Biochem Soc Trans 39:1527鈥?532. doi:10.鈥?042/鈥婤ST0391527
  Debono M, Turner WW, LaGrandeur L et al (1995) Semisynthetic chemical modification of the antifungal lipopeptide echinocandin B (ECB): structure鈥揳ctivity studies of the lipophilic and geometric parameters of polyarylated acyl analogs of ECB. J Med Chem 38:3271鈥?281
  DeCrescenzo Henriksen E, Phillips DR, Peterson JBD (2007) Polymyxin E production by P. amylolyticus. Lett Appl Microbiol 45:491鈥?96. doi:10.鈥?111/鈥媕.鈥?472-765X.鈥?007.鈥?2210.鈥媥
  Dehghan-Noude G, Housaindokht M, Bazzaz BSF (2005) Isolation, characterization, and investigation of surface and hemolytic activities of a lipopeptide biosurfactant produced by Bacillus subtilis ATCC 6633. J Microbiol 43:272鈥?76
  Deleu M, Bouffioux O, Razafindralambo H et al (2003) Interaction of surfactin with membranes: a computational approach. Langmuir 19:3377鈥?385. doi:10.鈥?021/鈥媗a026543z
  Dey G, Bharti R, Sen R, Mandal M (2014) Microbial amphiphiles: a class of promising new-generation anticancer agents. Drug Discov Today 20:136鈥?46. doi:10.鈥?016/鈥媕.鈥媎rudis.鈥?014.鈥?9.鈥?06
  Dey G, Bharti R, Dhanarajan G et al (2015) Marine lipopeptide Iturin A inhibits Akt mediated GSK3尾 and FoxO3a signaling and triggers apoptosis in breast cancer. Sci Rep 5:10316. doi:10.鈥?038/鈥媠rep10316
  Dijkmans AC, Wilms EB, Kamerling IMC et al (2014) Colistin: revival of an old polymyxin antibiotic. Ther Drug Monit. doi:10.鈥?097/鈥婩TD.鈥?000000000000172鈥?/span>
  Domalaon R, Yang X, O鈥橬eil J et al (2014) Structure鈥揳ctivity relationships in ultrashort cationic lipopeptides: the effects of amino acid ring constraint on antibacterial activity. Amino Acids 46:2517鈥?530. doi:10.鈥?007/鈥媠00726-014-1806-z
  Donio MBS, Ronica SFA, Viji VT et al (2013) Isolation and characterization of halophilic Bacillus sp. BS3 able to produce pharmacologically important biosurfactants. Asian Pac J Trop Med 6:876鈥?83. doi:10.鈥?016/鈥婼1995-7645(13)60156-X
  Duarte C, Gudi帽a EJ, Lima CF, Rodrigues LR (2014) Effects of biosurfactants on the viability and proliferation of human breast cancer cells. AMB Express 4:40. doi:10.鈥?186/鈥媠13568-014-0040-0
  Eeman M, Olofsson G, Sparr E et al (2014) Interaction of fengycin with stratum corneum mimicking model membranes: a calorimetry study. Colloids Surf B Biointerfaces 121:27鈥?5. doi:10.鈥?016/鈥媕.鈥媍olsurfb.鈥?014.鈥?5.鈥?19
  Eschenauer G, Depestel DD, Carver PL (2007) Comparison of echinocandin antifungals. Ther Clin Risk Manag 3:71鈥?7
  Falagas ME, Kasiakou SK (2006) Toxicity of polymyxins: a systematic review of the evidence from old and recent studies. Crit Care 10:R27. doi:10.鈥?186/鈥媍c3995
  Farace G, Fernandez O, Jacquens L et al (2014) Cyclic lipopeptides from Bacillus subtilis activate distinct patterns of defence responses in grapevine. Mol Plant Pathol. doi:10.鈥?111/鈥媘pp.鈥?2170
  Fischer A, Yang S-J, Bayer AS et al (2011) Daptomycin resistance mechanisms in clinically derived Staphylococcus aureus strains assessed by a combined transcriptomics and proteomics approach. J Antimicrob Chemother 66:1696鈥?711. doi:10.鈥?093/鈥媕ac/鈥媎kr195
  Gao Z, Zhao X, Lee S et al (2013) WH1fungin a surfactin cyclic lipopeptide is a novel oral immunoadjuvant. Vaccine 聽31:2796鈥?803聽doi:10.鈥?016/鈥媕.鈥媣accine.鈥?013.鈥?4.鈥?28.鈥?/span>
  Gao Z, Yang T, Zhao X et al (2014) Immunomodulation therapy of diabetes by oral administration of a surfactin lipopeptide in NOD mice. Vaccine. doi:10.鈥?016/鈥媕.鈥媣accine.鈥?014.鈥?8.鈥?82
  Gill KA, Berru茅 F, Arens JC, Kerr RG (2014) Isolation and structure elucidation of cystargamide, a lipopeptide from Kitasatospora cystarginea. J Nat Prod 77:1372鈥?376. doi:10.鈥?021/鈥媙p500122s
  Gong J, Zheng H, Wu Z et al (2009) Genome shuffling: progress and applications for phenotype improvement. Biotechnol Adv 27:996鈥?005. doi:10.鈥?016/鈥媕.鈥媌iotechadv.鈥?009.鈥?5.鈥?16
  Gong A-D, Li H-P, Yuan Q-S et al (2015) Antagonistic mechanism of iturin A and plipastatin A from Bacillus amyloliquefaciens S76-3 from wheat spikes against Fusarium graminearum. PLoS One 10:e0116871. doi:10.鈥?371/鈥媕ournal.鈥媝one.鈥?116871
  Gould IM, Mir贸 JM, Rybak MJ (2013) Daptomycin: the role of high-dose and combination therapy for Gram-positive infections. Int J Antimicrob Agents 42:202鈥?10. doi:10.鈥?016/鈥媕.鈥媔jantimicag.鈥?013.鈥?5.鈥?05
  Guo Q, Dong W, Li S et al (2014) Fengycin produced by Bacillus subtilis NCD-2 plays a major role in biocontrol of cotton seedling damping-off disease. Microbiol Res 169:533鈥?40. doi:10.鈥?016/鈥媕.鈥媘icres.鈥?013.鈥?2.鈥?01
  Gupta S, Govil D, Kakar PN et al (2009) Colistin and polymyxin B: a re-emergence. Indian J Crit Care Med 13:49鈥?3. doi:10.鈥?103/鈥?972-5229.鈥?6048
  Guti茅rrez Urb贸n JM, Linares Mond茅jar P, Martin Herranz I (2013) Daptomycin dosing greater than 6聽mg/kg/day depending on pharmacokinetic and pharmacodynamic parameters infections by Staphylococcus aureus. Farm Hosp 37:534鈥?38. doi:10.鈥?399/鈥婩H.鈥?013.鈥?7.鈥?.鈥?42
  Hajare SN, Subramanian M, Gautam S, Sharma A (2013) Induction of apoptosis in human cancer cells by a Bacillus lipopeptide bacillomycin D. Biochimie 95:1722鈥?731. doi:10.鈥?016/鈥媕.鈥媌iochi.鈥?013.鈥?5.鈥?15
  Hajfarajollah H, Mokhtarani B, Noghabi KA (2014) Newly antibacterial and antiadhesive lipopeptide biosurfactant secreted by a probiotic strain, Propionibacterium freudenreichii. Appl Biochem Biotechnol. doi:10.鈥?007/鈥媠12010-014-1221-7
  Han Q, Wu F, Wang X et al (2014) The bacterial lipopeptide iturins induce Verticillium dahliae cell death by affecting fungal signalling pathways and mediate plant defence responses involved in pathogen-associated molecular pattern-triggered immunity. Environ Microbiol. doi:10.鈥?111/鈥?462-2920.鈥?2538
  Hashizume H, Nishimura Y (2008) Bioactive natural products (Part O). Stud Nat Prod Chem. doi:10.鈥?016/鈥婼1572-5995(08)80016-6
  Horn JN, Cravens A, Grossfield A (2013) Interactions between fengycin and model bilayers quantified by coarse-grained molecular dynamics. Biophys J 105:1612鈥?623. doi:10.鈥?016/鈥媕.鈥媌pj.鈥?013.鈥?8.鈥?34
  Huang E, Yousef AE (2014a) The lipopeptide antibiotic paenibacterin binds to the bacterial outer membrane and exerts bactericidal activity through cytoplasmic membrane damage. Appl Environ Microbiol 80:2700鈥?704. doi:10.鈥?128/鈥婣EM.鈥?3775-13
  Huang E, Yousef AE (2014b) Paenibacterin, a novel broad-spectrum lipopeptide antibiotic, neutralises endotoxins and promotes survival in a murine model of Pseudomonas aeruginosa-induced sepsis. Int J Antimicrob Agents 44:74鈥?7. doi:10.鈥?016/鈥媕.鈥媔jantimicag.鈥?014.鈥?2.鈥?18
  Huang E, Guo Y, Yousef AE (2012) Draft genome sequence of Paenibacillus sp. strain OSY-SE, a bacterium producing the novel broad-spectrum lipopeptide antibiotic paenibacterin. J Bacteriol 194:6306. doi:10.鈥?128/鈥婮B.鈥?1506-12
  Huang E, Guo Y, Yousef AE (2014a) Biosynthesis of the new broad-spectrum lipopeptide antibiotic paenibacterin in Paenibacillus thiaminolyticus OSY-SE. Res Microbiol 165:243鈥?51. doi:10.鈥?016/鈥媕.鈥媟esmic.鈥?014.鈥?2.鈥?02
  Huang X-L, Wu J, Su T-T et al (2014b) Long-circulating liposomal daptomycin enhances protection against systemic methicillin-resistant Staphylococcus aureus infection with improved therapeutic potential. Yao Xue Xue Bao 49:701鈥?10
  Janek T, 艁ukaszewicz M, Rezanka T, Krasowska A (2010) Isolation and characterization of two new lipopeptide biosurfactants produced by Pseudomonas fluorescens BD5 isolated from water from the Arctic Archipelago of Svalbard. Bioresour Technol 101:6118鈥?123. doi:10.鈥?016/鈥媕.鈥媌iortech.鈥?010.鈥?2.鈥?09
  Janek T, 艁ukaszewicz M, Krasowska A (2012) Antiadhesive activity of the biosurfactant pseudofactin II secreted by the Arctic bacterium Pseudomonas fluorescens BD5. BMC Microbiol 12:24. doi:10.鈥?186/鈥?471-2180-12-24
  Janek T, Krasowska A, Radwa艅ska A, 艁ukaszewicz M (2013) Lipopeptide biosurfactant pseudofactin II induced apoptosis of melanoma A 375 cells by specific interaction with the plasma membrane. PLoS One 8:e57991. doi:10.鈥?371/鈥媕ournal.鈥媝one.鈥?057991
  Kanafani ZA, Corey GR (2007) Daptomycin: a rapidly bactericidal lipopeptide for the treatment of Gram-positive infections. Expert Rev Anti Infect Ther 5:177鈥?84. doi:10.鈥?586/鈥?4787210.鈥?.鈥?.鈥?77
  Kanaly RA, Harayama S (2000) Biodegradation of high-molecular-weight polycyclic aromatic hydrocarbons by bacteria. J Bacteriol 182:2059鈥?067
  Kanj SS, Kanafani ZA (2011) Current concepts in antimicrobial therapy against resistant gram-negative organisms: extended-spectrum beta-lactamase-producing Enterobacteriaceae, carbapenem-resistant Enterobacteriaceae, and multidrug-resistant Pseudomonas aeruginosa. Mayo Clin Proc 86:250鈥?59. doi:10.鈥?065/鈥媘cp.鈥?010.鈥?674
  Kaya S, Yilmaz G, Kalkan A et al (2013) Treatment of Gram-positive left-sided infective endocarditis with daptomycin. J Infect Chemother 19:698鈥?02. doi:10.鈥?007/鈥媠10156-012-0546-9
  Kelesidis T (2014) The interplay between daptomycin and the immune system. Front Immunol 5:52. doi:10.鈥?389/鈥媐immu.鈥?014.鈥?0052
  Kim S-Y, Kim JY, Kim S-H et al (2007) Surfactin from Bacillus subtilis displays anti-proliferative effect via apoptosis induction, cell cycle arrest and survival signaling suppression. FEBS Lett 581:865鈥?71. doi:10.鈥?016/鈥媕.鈥媐ebslet.鈥?007.鈥?1.鈥?59
  Kofla G, Ruhnke M (2011) Pharmacology and metabolism of anidulafungin, caspofungin and micafungin in the treatment of invasive candidosis: review of the literature. Eur J Med Res 16:159鈥?66
  Kwa A, Kasiakou SK, Tam VH, Falagas ME (2007) Polymyxin B: similarities to and differences from colistin (polymyxin E). Expert Rev Anti Infect Ther 5:811鈥?21. doi:10.鈥?586/鈥?4787210.鈥?.鈥?.鈥?11
  Lal B, Gund VG, Gangopadhyay AK et al (2003) Semisynthetic modifications of hemiaminal function at ornithine unit of mulundocandin, towards chemical stability and antifungal activity. Bioorg Med Chem 11:5189鈥?198
  Landman D, Georgescu C, Martin DA, Quale J (2008) Polymyxins revisited. Clin Microbiol Rev 21:449鈥?65. doi:10.鈥?128/鈥婥MR.鈥?0006-08
  Laverty G, Gorman SP, Gilmore BF (2011) The potential of antimicrobial peptides as biocides. Int J Mol Sci 12:6566鈥?596. doi:10.鈥?390/鈥媔jms12106566
  Lawrance A, Balakrishnan M, Joseph TC et al (2014) Functional and molecular characterization of a lipopeptide surfactant from the marine sponge-associated eubacteria Bacillus licheniformis NIOT-AMKV06 of Andaman and Nicobar Islands, India. Mar Pollut Bull 82:76鈥?5. doi:10.鈥?016/鈥媕.鈥媘arpolbul.鈥?014.鈥?3.鈥?18
  Lechner S, Prax M, Lange B et al (2014) Metabolic and transcriptional activities of Staphylococcus aureus challenged with high-doses of daptomycin. Int J Med Microbiol. doi:10.鈥?016/鈥媕.鈥媔jmm.鈥?014.鈥?5.鈥?08
  Lee JH, Nam SH, Seo WT et al (2012) The production of surfactin during the fermentation of cheonggukjang by potential probiotic Bacillus subtilis CSY191 and the resultant growth suppression of MCF-7 human breast cancer cells. Food Chem 131:1347鈥?354. doi:10.鈥?016/鈥媕.鈥媐oodchem.鈥?011.鈥?9.鈥?33
  Lim LM, Ly N, Anderson D et al (2010) Resurgence of colistin: a review of resistance, toxicity, pharmacodynamics, and dosing. Pharmacotherapy 30:1279鈥?291. doi:10.鈥?592/鈥媝hco.鈥?0.鈥?2.鈥?279
  Lohans CT, van Belkum MJ, Cochrane SA et al (2014) Biochemical, structural, and genetic characterization of tridecaptin A1, an antagonist of Campylobacter jejuni. ChemBioChem 15:243鈥?49. doi:10.鈥?002/鈥媍bic.鈥?01300595
  Lora-Tamayo J, Parra-Ruiz J, Rodr铆guez-Pardo D et al (2014) High doses of daptomycin (10聽mg/kg/d) plus rifampin for the treatment of staphylococcal prosthetic joint infection managed with implant retention: a comparative study. Diagn Microbiol Infect Dis 80:66鈥?1. doi:10.鈥?016/鈥媕.鈥媎iagmicrobio.鈥?014.鈥?5.鈥?22
  Luo C, Liu X, Zhou H et al (2015) Nonribosomal peptide synthase gene clusters for lipopeptide biosynthesis in Bacillus subtilis 916 and their phenotypic functions. Appl Environ Microbiol 81:422鈥?31. doi:10.鈥?128/鈥婣EM.鈥?2921-14
  Lynch SA, Gill RT (2012) Synthetic biology: new strategies for directing design. Metab Eng 14:205鈥?11. doi:10.鈥?016/鈥媕.鈥媦mben.鈥?011.鈥?2.鈥?07
  Malina A, Shai Y (2005) Conjugation of fatty acids with different lengths modulates the antibacterial and antifungal activity of a cationic biologically inactive peptide. Biochem J 390:695鈥?02. doi:10.鈥?042/鈥婤J20050520
  Mandal SM, Barbosa AEAD, Franco OL (2013a) Lipopeptides in microbial infection control: scope and reality for industry. Biotechnol Adv 31:338鈥?45. doi:10.鈥?016/鈥媕.鈥媌iotechadv.鈥?013.鈥?1.鈥?04
  Mandal SM, Sharma S, Pinnaka AK et al (2013b) Isolation and characterization of diverse antimicrobial lipopeptides produced by Citrobacter and Enterobacter. BMC Microbiol 13:152. doi:10.鈥?186/鈥?471-2180-13-152
  Martin NI, Hu H, Moake MM et al (2003) Isolation, structural characterization, and properties of mattacin (polymyxin M), a cyclic peptide antibiotic produced by Paenibacillus kobensis M. J Biol Chem 278:13124鈥?3132. doi:10.鈥?074/鈥媕bc.鈥婱212364200
  McConoughey SJ, Howlin R, Granger JF et al (2014) Biofilms in periprosthetic orthopedic infections. Future Microbiol 9:987鈥?007. doi:10.鈥?217/鈥媐mb.鈥?4.鈥?4
  Meena KR, Kanwar SS (2015) Lipopeptides as the antifungal and antibacterial agents: applications in food safety and therapeutics. Biomed Res Int 2015:473050. doi:10.鈥?155/鈥?015/鈥?73050
  Miao V, Co毛ffet-Le Gal M-F, Nguyen K et al (2006) Genetic engineering in Streptomyces roseosporus to produce hybrid lipopeptide antibiotics. Chem Biol 13:269鈥?76. doi:10.鈥?016/鈥媕.鈥媍hembiol.鈥?005.鈥?2.鈥?12
  Mitchell W (2011) Natural products from synthetic biology. Curr Opin Chem Biol 15:505鈥?15. doi:10.鈥?016/鈥媕.鈥媍bpa.鈥?011.鈥?5.鈥?17
  Mittenb眉hler K, Loleit M, Baier W et al (1997) Drug specific antibodies: T-cell epitope-lipopeptide conjugates are potent adjuvants for small antigens in vivo and in vitro. Int J Immunopharmacol 19:277鈥?87
  Moyle PM, Toth I (2008) Self-adjuvanting lipopeptide vaccines. Curr Med Chem 15:506鈥?16
  Murata D, Sawano S, Ohike T et al (2013) Isolation of antifungal bacteria from Japanese fermented soybeans, natto. J Environ Sci (China) 25(Suppl 1):S127鈥揝131. doi:10.鈥?016/鈥婼1001-0742(14)60641-0
  Naing KW, Lee YS, Nguyen XH et al (2015) Isolation and characterization of an antimicrobial lipopeptide produced by Paenibacillus ehimensis MA2012. J Basic Microbiol. doi:10.鈥?002/鈥媕obm.鈥?01400505
  Nasir MN, Laurent P, Flore C et al (2013) Analysis of calcium-induced effects on the conformation of fengycin. Spectrochim Acta A Mol Biomol Spectrosc 110:450鈥?57. doi:10.鈥?016/鈥媕.鈥媠aa.鈥?013.鈥?3.鈥?63
  Nerurkar AS (2010) Structural and molecular characteristics of lichenysin and its relationship with surface activity. Adv Exp Med Biol 672:304鈥?15
  Ochi K, Hosaka T (2013) New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters. Appl Microbiol Biotechnol 97:87鈥?8. doi:10.鈥?007/鈥媠00253-012-4551-9
  Oftedal L, Myhren L, Jokela J et al (2012) The lipopeptide toxins anabaenolysin A and B target biological membranes in a cholesterol-dependent manner. Biochim Biophys Acta 1818:3000鈥?009. doi:10.鈥?016/鈥媕.鈥媌bamem.鈥?012.鈥?7.鈥?15
  Ongena M, Jacques P (2008) Bacillus lipopeptides: versatile weapons for plant disease biocontrol. Trends Microbiol 16:115鈥?25. doi:10.鈥?016/鈥媕.鈥媡im.鈥?007.鈥?2.鈥?09
  Ort铆z-L贸pez FJ, Monteiro MC, Gonz谩lez-Men茅ndez V et al (2015) Cyclic colisporifungin and linear cavinafungins antifungal lipopeptides isolated from Colispora cavincola. J Nat Prod. doi:10.鈥?021/鈥媙p500854j
  Pacwa-P艂ociniczak M, P艂aza GA, Poliwoda A, Piotrowska-Seget Z (2014) Characterization of hydrocarbon-degrading and biosurfactant-producing Pseudomonas sp. P-1 strain as a potential tool for bioremediation of petroleum-contaminated soil. Environ Sci Pollut Res Int 21:9385鈥?395. doi:10.鈥?007/鈥媠11356-014-2872-1
  Pan H, Zhao X, Gao Z, Qi G (2014) A surfactin lipopeptide adjuvanted hepatitis B vaccines elicit enhanced humoral and cellular immune responses in mice. Protein Pept Lett 21:901鈥?10
  Pappas G, Ierodiakonou V, Falagas ME (2009) Lost in translation: differences in antimicrobial indication approval policies between the United States and Europe. Clin Ther 31:1595鈥?603. doi:10.鈥?016/鈥媕.鈥媍linthera.鈥?009.鈥?6.鈥?16
  Patel H, Huynh Q, B盲rlehner D, Heerklotz H (2014) Additive and synergistic membrane permeabilization by antimicrobial (lipo)peptides and detergents. Biophys J 106:2115鈥?125. doi:10.鈥?016/鈥媕.鈥媌pj.鈥?014.鈥?4.鈥?06
  Pathak KV, Keharia H (2013) Identification of surfactins and iturins produced by potent fungal antagonist, Bacillus subtilis K1 isolated from aerial roots of banyan (Ficus benghalensis) tree using mass spectrometry. 3. Biotech 4:283鈥?95. doi:10.鈥?007/鈥媠13205-013-0151-3
  Peel TN, Buising KL, Choong PFM (2012) Diagnosis and management of prosthetic joint infection. Curr Opin Infect Dis 25:670鈥?76. doi:10.鈥?097/鈥婹CO.鈥?b013e32835915db鈥?/span>
  Peng W, Zhong J, Yang J et al (2014) The artificial neural network approach based on uniform design to optimize the fed-batch fermentation condition: application to the production of iturin A. Microb Cell Fact 13:54. doi:10.鈥?186/鈥?475-2859-13-54
  Qazi MA, Kanwal T, Jadoon M et al (2014) Isolation and characterization of a biosurfactant-producing Fusarium sp. BS-8 from oil contaminated soil. Biotechnol Prog 30:1065鈥?075. doi:10.鈥?002/鈥媌tpr.鈥?933
  Qi G, Zhu F, Du P et al (2010) Lipopeptide induces apoptosis in fungal cells by a mitochondria-dependent pathway. Peptides 31:1978鈥?986. doi:10.鈥?016/鈥媕.鈥媝eptides.鈥?010.鈥?8.鈥?03
  Qian C-D, Liu T-Z, Zhou S-L et al (2012a) Identification and functional analysis of gene cluster involvement in biosynthesis of the cyclic lipopeptide antibiotic pelgipeptin produced by Paenibacillus elgii. BMC Microbiol 12:197. doi:10.鈥?186/鈥?471-2180-12-197
  Qian C-D, Wu X-C, Teng Y et al (2012b) Battacin (Octapeptin B5), a new cyclic lipopeptide antibiotic from Paenibacillus tianmuensis active against multidrug-resistant Gram-negative bacteria. Antimicrob Agents Chemother 56:1458鈥?465. doi:10.鈥?128/鈥婣AC.鈥?5580-11
  Raaijmakers JM, De Bruijn I, Nybroe O, Ongena M (2010) Natural functions of lipopeptides from Bacillus and Pseudomonas: more than surfactants and antibiotics. FEMS Microbiol Rev 34:1037鈥?062. doi:10.鈥?111/鈥媕.鈥?574-6976.鈥?010.鈥?0221.鈥媥
  Rautela R, Singh AK, Shukla A, Cameotra SS (2014) Lipopeptides from Bacillus strain AR2 inhibits biofilm formation by Candida albicans. Antonie Van Leeuwenhoek 105:809鈥?21. doi:10.鈥?007/鈥媠10482-014-0135-2
  Reder-Christ K, Schmidt Y, D枚rr M et al (2012) Model membrane studies for characterization of different antibiotic activities of lipopeptides from Pseudomonas. Biochim Biophys Acta 1818:566鈥?73. doi:10.鈥?016/鈥媕.鈥媌bamem.鈥?011.鈥?8.鈥?07
  Robbel L, Marahiel MA (2010) Daptomycin, a bacterial lipopeptide synthesized by a nonribosomal machinery. J Biol Chem 285:27501鈥?7508. doi:10.鈥?074/鈥媕bc.鈥婻110.鈥?28181
  Rodrigues LR (2015) Microbial surfactants: fundamentals and applicability in the formulation of nano-sized drug delivery vectors. J Colloid Interface Sci. doi:10.鈥?016/鈥媕.鈥媕cis.鈥?015.鈥?1.鈥?22
  Roongsawang N, Washio K, Morikawa M (2010) Diversity of nonribosomal peptide synthetases involved in the biosynthesis of lipopeptide biosurfactants. Int J Mol Sci 12:141鈥?72. doi:10.鈥?390/鈥媔jms12010141
  R眉ckert C, Szczepanowski R, Albersmeier A et al (2014) Complete genome sequence of the actinobacterium Actinoplanes friuliensis HAG 010964, producer of the lipopeptide antibiotic friulimycin. J Biotechnol 178:41鈥?2. doi:10.鈥?016/鈥媕.鈥媕biotec.鈥?014.鈥?3.鈥?11
  Sagar SM, Yance D, Wong RK (2006) Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 1. Curr Oncol 13:14鈥?6
  Sakoulas G, Moise PA, Casapao AM et al (2014) Antimicrobial salvage therapy for persistent staphylococcal bacteremia using daptomycin plus ceftaroline. Clin Ther 36:1317鈥?333. doi:10.鈥?016/鈥媕.鈥媍linthera.鈥?014.鈥?5.鈥?61
  Salunke DB, Connelly SW, Shukla NM et al (2013) Design and development of stable, water-soluble, human Toll-like receptor 2 specific monoacyl lipopeptides as candidate vaccine adjuvants. J Med Chem 56:5885鈥?900. doi:10.鈥?021/鈥媕m400620g
  Schneider T, Gries K, Josten M et al (2009) The lipopeptide antibiotic Friulimicin B inhibits cell wall biosynthesis through complex formation with bactoprenol phosphate. Antimicrob Agents Chemother 53:1610鈥?618. doi:10.鈥?128/鈥婣AC.鈥?1040-08
  Schneider T, M眉ller A, Miess H, Gross H (2014) Cyclic lipopeptides as antibacterial agents鈥攑otent antibiotic activity mediated by intriguing mode of actions. Int J Med Microbiol 304:37鈥?3. doi:10.鈥?016/鈥媕.鈥媔jmm.鈥?013.鈥?8.鈥?09
  Seydlov谩 G, Fi拧er R, Cabala R et al (2013) Surfactin production enhances the level of cardiolipin in the cytoplasmic membrane of Bacillus subtilis. Biochim Biophys Acta 1828:2370鈥?378. doi:10.鈥?016/鈥媕.鈥媌bamem.鈥?013.鈥?6.鈥?32
  Shao C, Liu L, Gang H et al (2015) Structural diversity of the microbial surfactin derivatives from selective esterification approach. Int J Mol Sci 16:1855鈥?872. doi:10.鈥?390/鈥媔jms16011855
  Sharma D, Mandal SM, Manhas RK (2014) Purification and characterization of a novel lipopeptide from Streptomyces amritsarensis sp. nov. active against methicillin-resistant Staphylococcus aureus. AMB Express 4:50. doi:10.鈥?186/鈥媠13568-014-0050-y
  Shen K-Y, Chang L-S, Leng C-H, Liu S-J (2015) Self-adjuvanting lipoimmunogens for therapeutic HPV vaccine development: potential clinical impact. Expert Rev Vaccines 14:383鈥?94. doi:10.鈥?586/鈥?4760584.鈥?015.鈥?66696
  Shiono Y, Tsuchinari M, Shimanuki K et al (2007) Fusaristatins A and B, two new cyclic lipopeptides from an endophytic Fusarium sp. J Antibiot (Tokyo) 60:309鈥?16. doi:10.鈥?038/鈥媕a.鈥?007.鈥?9
  Shoemaker DM, Simou J, Roland WE (2006) A review of daptomycin for injection (Cubicin) in the treatment of complicated skin and skin structure infections. Ther Clin Risk Manag 2:169鈥?74
  Silverman JA, Perlmutter NG, Shapiro HM (2003) Correlation of daptomycin bactericidal activity and membrane depolarization in Staphylococcus aureus. Antimicrob Agents Chemother 47:2538鈥?544
  Singh AK, Rautela R, Cameotra SS (2014a) Substrate dependent in vitro antifungal activity of Bacillus sp. strain AR2. Microb Cell Fact 13:67. doi:10.鈥?186/鈥?475-2859-13-67
  Singh LS, Sharma H, Talukdar NC (2014b) Production of potent antimicrobial agent by actinomycete, Streptomyces sannanensis strain SU118 isolated from phoomdi in Loktak Lake of Manipur, India. BMC Microbiol 14:278. doi:10.鈥?186/鈥媠12866-014-0278-3
  Sivapathasekaran C, Das P, Mukherjee S et al (2010) Marine bacterium derived lipopeptides: characterization and cytotoxic activity against cancer cell lines. Int J Pept Res Ther 16:215鈥?22. doi:10.鈥?007/鈥媠10989-010-9212-1
  Song C, Aundy K, van de Mortel J, Raaijmakers JM (2014) Discovery of new regulatory genes of lipopeptide biosynthesis in Pseudomonas fluorescens. FEMS Microbiol Lett 356:166鈥?75
  Steenbergen JN, Alder J, Thorne GM, Tally FP (2005) Daptomycin: a lipopeptide antibiotic for the treatment of serious Gram-positive infections. J Antimicrob Chemother 55:283鈥?88. doi:10.鈥?093/鈥媕ac/鈥媎kh546
  Steinhagen F, Kinjo T, Bode C, Klinman DM (2011) TLR-based immune adjuvants. Vaccine 29:3341鈥?355. doi:10.鈥?016/鈥媕.鈥媣accine.鈥?010.鈥?8.鈥?02
  Strano CP, Bella P, Licciardello G et al (2015) Pseudomonas corrugata crpCDE is part of the cyclic lipopeptide corpeptin biosynthetic gene cluster and is involved in bacterial virulence in tomato and in hypersensitive response in Nicotiana benthamiana. Mol Plant Pathol. doi:10.鈥?111/鈥媘pp.鈥?2207
  Strieker M, Tanovi膰 A, Marahiel MA (2010) Nonribosomal peptide synthetases: structures and dynamics. Curr Opin Struct Biol 20:234鈥?40. doi:10.鈥?016/鈥媕.鈥媠bi.鈥?010.鈥?1.鈥?09
  Sun H, Bie X, Lu F et al (2009) Enhancement of surfactin production of Bacillus subtilis fmbR by replacement of the native promoter with the Pspac promoter. Can J Microbiol 55:1003鈥?006. doi:10.鈥?139/鈥媤09-044
  Sun H, Liu Z, Zhao H, Ang EL (2015) Recent advances in combinatorial biosynthesis for drug discovery. Drug Des Devel Ther 9:823鈥?33. doi:10.鈥?147/鈥婦DDT.鈥婼63023
  Takeuchi M, Ashihara E, Yamazaki Y et al (2011) Rakicidin A effectively induces apoptosis in hypoxia adapted Bcr-Abl positive leukemic cells. Cancer Sci 102:591鈥?96. doi:10.鈥?111/鈥媕.鈥?349-7006.鈥?010.鈥?1813.鈥媥
  Tang J, Gao H, Dai Y et al (2008) Progress on the studies of cyclic lipopeptides. Yao Xue Xue Bao 43:873鈥?83
  Tareq FS, Lee MA, Lee H-S et al (2014) Gageotetrins A鈥揅, noncytotoxic antimicrobial linear lipopeptides from a marine bacterium Bacillus subtilis. Org Lett 16:928鈥?31. doi:10.鈥?021/鈥媜l403657r
  Thasana N, Prapagdee B, Rangkadilok N et al (2010) Bacillus subtilis SSE4 produces subtulene A, a new lipopeptide antibiotic possessing an unusual C15 unsaturated beta-amino acid. FEBS Lett 584:3209鈥?214. doi:10.鈥?016/鈥媕.鈥媐ebslet.鈥?010.鈥?6.鈥?05
  Thies S, Santiago-Sch眉bel B, Kova膷i膰 F et al (2014) Heterologous production of the lipopeptide biosurfactant serrawettin W1 in Escherichia coli. J Biotechnol 181:27鈥?0. doi:10.鈥?016/鈥媕.鈥媕biotec.鈥?014.鈥?3.鈥?37
  Tirilomis T (2014) Daptomycin and its immunomodulatory effect: consequences for antibiotic treatment of methicillin-resistant Staphylococcus aureus wound infections after heart surgery. Front Immunol 5:97. doi:10.鈥?389/鈥媐immu.鈥?014.鈥?0097
  Toth I, Simerska P, Fujita Y (2008) Recent advances in design and synthesis of self-adjuvanting lipopeptide vaccines. Int J Pept Res Ther 14:333鈥?40. doi:10.鈥?007/鈥媠10989-008-9147-y
  Velkov T, Roberts KD, Nation RL et al (2013) Pharmacology of polymyxins: new insights into an 鈥渙ld鈥?class of antibiotics. Future Microbiol 8:711鈥?24. doi:10.鈥?217/鈥媐mb.鈥?3.鈥?9
  Vilela WFD, Fonseca SG, Fantinatti-Garboggini F et al (2014) Production and properties of a surface-active lipopeptide produced by a new marine Brevibacterium luteolum strain. Appl Biochem Biotechnol. doi:10.鈥?007/鈥媠12010-014-1208-4
  Walsh CT (2002) Combinatorial biosynthesis of antibiotics: challenges and opportunities. ChemBioChem 3:125鈥?34
  Wang CL, Ng TB, Cao XH et al (2009) CLP induces apoptosis in human leukemia K562 cells through Ca(2+) regulating extracellular-related protein kinase ERK activation. Cancer Lett 276:221鈥?27. doi:10.鈥?016/鈥媕.鈥媍anlet.鈥?008.鈥?1.鈥?07
  Wang F, Ren N-N, Luo S et al (2014) DptR2, a DeoR-type auto-regulator, is required for daptomycin production in Streptomyces roseosporus. Gene 544:208鈥?15. doi:10.鈥?016/鈥媕.鈥媑ene.鈥?014.鈥?4.鈥?44
  Xia W, Du Z, Cui Q et al (2014) Biosurfactant produced by novel Pseudomonas sp. WJ6 with biodegradation of n-alkanes and polycyclic aromatic hydrocarbons. J Hazard Mater 276:489鈥?98. doi:10.鈥?016/鈥媕.鈥媕hazmat.鈥?014.鈥?5.鈥?62
  Xing Y, Wang W, Dai S et al (2014) Daptomycin exerts rapid bactericidal activity against Bacillus anthracis without disrupting membrane integrity. Acta Pharmacol Sin 35:211鈥?18. doi:10.鈥?038/鈥媋ps.鈥?013.鈥?59
  Yamanaka K, Reynolds KA, Kersten RD et al (2014) Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proc Natl Acad Sci U S A 111:1957鈥?962. doi:10.鈥?073/鈥媝nas.鈥?319584111
  Yang S-Z, Wei D-Z, Mu B-Z (2006) Determination of the amino acid sequence in a cyclic lipopeptide using MS with DHT mechanism. J Biochem Biophys Methods 68:69鈥?4. doi:10.鈥?016/鈥媕.鈥媕bbm.鈥?006.鈥?3.鈥?08
  Yang H, Chen G, Hu L et al (2014a) In vivo activity of daptomycin/colistin combination therapy in a Galleria mellonella model of Acinetobacter baumannii infection. Int J Antimicrob Agents. doi:10.鈥?016/鈥媕.鈥媔jantimicag.鈥?014.鈥?0.鈥?12
  Yang H-J, Huang X-Z, Zhang Z-L et al (2014b) Two novel amphomycin analogues from Streptomyces canus strain FIM-0916. Nat Prod Res 28:861鈥?67. doi:10.鈥?080/鈥?4786419.鈥?014.鈥?86210
  Yoshino N, Endo M, Kanno H et al (2013) Polymyxins as novel and safe mucosal adjuvants to induce humoral immune responses in mice. PLoS One 8:e61643. doi:10.鈥?371/鈥媕ournal.鈥媝one.鈥?061643
  Yu Z, Qin W, Lin J et al (2015) Antibacterial mechanisms of polymyxin and bacterial resistance. Biomed Res Int 2015:679109. doi:10.鈥?155/鈥?015/鈥?79109
  Yuste JR, Quesada M, D铆az-Rada P, Del Pozo JL (2014) Daptomycin in the treatment of prosthetic joint infection by Enterococcus faecalis: safety and efficacy of high-dose and prolonged therapy. Int J Infect Dis 27:65鈥?6. doi:10.鈥?016/鈥媕.鈥媔jid.鈥?014.鈥?5.鈥?34
  Zaman M, Toth I (2013) Immunostimulation by synthetic lipopeptide-based vaccine candidates: structure鈥揳ctivity relationships. Front Immunol 4:318. doi:10.鈥?389/鈥媐immu.鈥?013.鈥?0318
  Zeriouh H, Romero D, Garcia-Gutierrez L et al (2011) The iturin-like lipopeptides are essential components in the biological control arsenal of Bacillus subtilis against bacterial diseases of cucurbits. Mol Plant Microbe Interact 24:1540鈥?552. doi:10.鈥?094/鈥婱PMI-06-11-0162
  Zhang A, Sun H, Wang P et al (2012) Modern analytical techniques in metabolomics analysis. Analyst 137:293鈥?00. doi:10.鈥?039/鈥媍1an15605e
  Zhang B, Dong C, Shang Q et al (2013a) New insights into membrane-active action in plasma membrane of fungal hyphae by the lipopeptide antibiotic bacillomycin L. Biochim Biophys Acta 1828:2230鈥?237. doi:10.鈥?016/鈥媕.鈥媌bamem.鈥?013.鈥?5.鈥?33
  Zhang T, Muraih JK, Mintzer E et al (2013b) Mutual inhibition through hybrid oligomer formation of daptomycin and the semisynthetic lipopeptide antibiotic CB-182,462. Biochim Biophys Acta 1828:302鈥?08. doi:10.鈥?016/鈥媕.鈥媌bamem.鈥?012.鈥?0.鈥?08
  Zhang P, Lu J, Huang Y et al (2014a) Design and evaluation of a PEGylated lipopeptide equipped with drug-interactive motifs as an improved drug carrier. AAPS J 16:114鈥?24. doi:10.鈥?208/鈥媠12248-013-9536-9
  Zhang T, Muraih JK, MacCormick B et al (2014b) Daptomycin forms cation- and size-selective pores in model membranes. Biochim Biophys Acta 1838:2425鈥?430. doi:10.鈥?016/鈥媕.鈥媌bamem.鈥?014.鈥?5.鈥?14
  Zhang T, Muraih JK, Tishbi N et al (2014c) Cardiolipin prevents membrane translocation and permeabilization by daptomycin. J Biol Chem 289:11584鈥?1591. doi:10.鈥?074/鈥媕bc.鈥婱114.鈥?54444
  Zhao J, Li Y, Zhang C et al (2012) Genome shuffling of Bacillus amyloliquefaciens for improving antimicrobial lipopeptide production and an analysis of relative gene expression using FQ RT-PCR. J Ind Microbiol Biotechnol 39:889鈥?96. doi:10.鈥?007/鈥媠10295-012-1098-9
  Zhao J, Cao L, Zhang C et al (2014) Differential proteomics analysis of Bacillus amyloliquefaciens and its genome-shuffled mutant for improving surfactin production. Int J Mol Sci 15:19847鈥?9869. doi:10.鈥?390/鈥媔jms151119847
  
• 作者单位：Seema Patel (1)
  Shadab Ahmed (2)
  J. Satya Eswari (3)
  
  1. Bioinformatics and Medical Informatics Research Center, San Diego State University, San Diego, CA, 92182, USA
  2. Institute of Bioinformatics and Biotechnology (IBB), Savitribai Phule Pune University, Pune, 411007, India
  3. Department of Biotechnology, National Institute of Technology Raipur, Raipur, 492010, India
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Applied Microbiology
  Biotechnology
  Biochemistry
  Environmental Biotechnology
  Microbiology
  
• 出版者：Springer Netherlands
• ISSN：1573-0972

文摘

Infectious diseases impose serious public health burdens and often have devastating consequences. The cyclic lipopeptides elaborated by bacteria Bacillus, Paenibacillus, Pseudomonas, Streptomyces, Serratia, Propionibacterium and fungus Fusarium are very crucial in restraining the pathogens. Composed of a peptide and a fatty acyl moiety these amphiphilic metabolites exhibit broad spectrum antimicrobial effects. Among the plethora of cyclic lipopeptides, only selective few have emerged as robust antibiotics. For their functional vigor, polymyxin, daptomycin, surfactin, iturin, fengysin, paenibacterin and pseudofactin have been integrated in mainstream healthcare. Daptomycin has been a significant part of antimicrobial arsenal since the past decade. As the magnitude of drug resistance rises in unprecedented manner, the urgency of prospecting novel cyclic lipopeptides is being perceived. Intense research has revealed the implication of these bioactive compounds stretching beyond antibacterial and antifungal. Anticancer, immunomodulatory, prosthetic parts disinfection and vaccine adjuvancy are some of the validated prospects. This review discusses the emerging applications, mechanisms governing the biological actions, role of genomics in refining structure and function, semi-synthetic analog discovery, novel strain isolation, setbacks etc. Though its beyond the scope of the current topic, for holistic purpose, the role of lipopeptides in bioremediation and crop biotechnology has been briefly outlined. This updated critique is expected to galvanize innovations and diversify therapeutic recruitment of microbial lipopeptides.