Association Between the Occurrence of Adverse Drug Events and Modification of First-Line Highly Active Antiretroviral Therapy in Ghanaian HIV Patients

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• 作者：Raymond A. Tetteh ; Edmund T. Nartey ; Margaret Lartey…
• 刊名：Drug Safety
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：39
• 期：11
• 页码：1139-1149
• 全文大小：451 KB
• 刊物主题：Drug Safety and Pharmacovigilance; Pharmacology/Toxicology;
• 出版者：Springer International Publishing
• ISSN：1179-1942
• 卷排序：39

文摘

IntroductionPatients initiated on highly active antiretroviral therapy (HAART) generally remain on medication indefinitely. A modification in the HAART regimen may become necessary because of possible acute or chronic toxicities, concomitant clinical conditions, development of virological failure or the advent of adverse drug events. The study documents adverse drug events of HIV-positive Ghanaian patients with HAART modifications. It also investigates the association between documented adverse drug events and HAART modification using an unmatched case–control study design.