Role of surface charge and oxidative stress in cytotoxicity of organic monolayer-coated silicon nanoparticles towards macrophage NR8383 cells
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- 作者：Sourav Bhattacharjee (1) (2)
Laura HJ de Haan (1)
Nynke M Evers (1)
Xue Jiang (1)
Antonius TM Marcelis (2)
Han Zuilhof (2)
Ivonne MCM Rietjens (1)
Gerrit M Alink (1) - 刊名：Particle and Fibre Toxicology
- 出版年：2010
- 出版时间：December 2010
- 年：2010
- 卷：7
- 期：1
- 全文大小：789KB
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50. Supino R: Methods in Molecular Biology. In / Vitro Toxicity Testing Protocols. / Volume 43. Edited by: S. O'Hare and C. K. Atterwill. Humana Press, Totowa, NJ; Ch. 16 - 作者单位：Sourav Bhattacharjee (1) (2)
Laura HJ de Haan (1)
Nynke M Evers (1)
Xue Jiang (1)
Antonius TM Marcelis (2)
Han Zuilhof (2)
Ivonne MCM Rietjens (1)
Gerrit M Alink (1)
1. Division of Toxicology, Wageningen University, PO Box 8000, 6700, EA, Wageningen, The Netherlands
2. Laboratory of Organic Chemistry, Wageningen University, Dreijenplein 8, 6703, HB, Wageningen, The Netherlands
文摘
Background Surface charge and oxidative stress are often hypothesized to be important factors in cytotoxicity of nanoparticles. However, the role of these factors is not well understood. Hence, the aim of this study was to systematically investigate the role of surface charge, oxidative stress and possible involvement of mitochondria in the production of intracellular reactive oxygen species (ROS) upon exposure of rat macrophage NR8383 cells to silicon nanoparticles. For this aim highly monodisperse (size 1.6 ± 0.2 nm) and well-characterized Si core nanoparticles (Si NP) were used with a surface charge that depends on the specific covalently bound organic monolayers: positively charged Si NP-NH2, neutral Si NP-N3 and negatively charged Si NP-COOH. Results Positively charged Si NP-NH2 proved to be more cytotoxic in terms of reducing mitochondrial metabolic activity and effects on phagocytosis than neutral Si NP-N3, while negatively charged Si NP-COOH showed very little or no cytotoxicity. Si NP-NH2 produced the highest level of intracellular ROS, followed by Si NP-N3 and Si NP-COOH; the latter did not induce any intracellular ROS production. A similar trend in ROS production was observed in incubations with an isolated mitochondrial fraction from rat liver tissue in the presence of Si NP. Finally, vitamin E and vitamin C induced protection against the cytotoxicity of the Si NP-NH2 and Si NP-N3, corroborating the role of oxidative stress in the mechanism underlying the cytotoxicity of these Si NP. Conclusion Surface charge of Si-core nanoparticles plays an important role in determining their cytotoxicity. Production of intracellular ROS, with probable involvement of mitochondria, is an important mechanism for this cytotoxicity.