The dimensions of clinical and cognitive change in schizophrenia: evidence for independence of improvements

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• 作者：Philip D. Harvey ; Michael F. Green ; Christopher Bowie and Antony Loebel
• 关键词：Schizophrenia ; Clinical effectiveness ; Cognitive function ; Antipsychotic ; Treatment
• 刊名：Psychopharmacology
• 出版年：2006
• 出版时间：August, 2006
• 年：2006
• 卷：187
• 期：3
• 页码：356-363
• 全文大小：162 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2072

文摘

Background As cognitive impairments are related to deficits in everyday functioning in schizophrenia, treatment of these impairments may have the potential to reduce these functional deficits. To determine if treatments truly reduce cognitive impairment, it is important to discriminate direct cognitive effects of treatment from generalized treatment benefits on the multiple clinical dimensions of schizophrenia. Thus, this study used a database from an existing clinical trial and examined the relationships between changes in clinical symptoms and cognitive deficits with several different strategies.