Influence of processing parameters and solid concentration on microstructural properties of gel-casted porous hydroxyapatite

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• 作者：Anila Asif (1)
  Rabia Nazir (1)
  Tehseen Riaz (1)
  Nafisa Ashraf (1)
  Saba Zahid (1)
  Ramla Shahid (2)
  Anis Ur-Rehman (3)
  Aqif Anwar Chaudhry (1)
  Ihtesham Ur Rehman (1) (4)
  
• 关键词：Gel ; casting ; Hydroxyapatite ; Porous scaffolds ; Interconnected porosity ; Biocompatibility
• 刊名：Journal of Porous Materials
• 出版年：2014
• 出版时间：February 2014
• 年：2014
• 卷：21
• 期：1
• 页码：31-37
• 全文大小：474 KB
• 作者单位：Anila Asif (1)
  Rabia Nazir (1)
  Tehseen Riaz (1)
  Nafisa Ashraf (1)
  Saba Zahid (1)
  Ramla Shahid (2)
  Anis Ur-Rehman (3)
  Aqif Anwar Chaudhry (1)
  Ihtesham Ur Rehman (1) (4)
  
  1. Interdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS Institute of Information Technology, Defence Road, Off Raiwind Road, Lahore, 56000, Pakistan
  2. Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, 44000, Pakistan
  3. Department of Physics, COMSATS Institute of Information Technology, Islamabad, 44000, Pakistan
  4. Department of Material Science and Engineering, The Kroto Research Institute, University of Sheffield, Sheffield, S3 7HQ, UK
  
• ISSN：1573-4854

文摘

Porous hydroxyapatite (HA) scaffolds with interconnected porosity have been successfully fabricated by using food grade gelatin as a gelling agent. Phase stability, chemical composition and topographical features of HA scaffolds were evaluated by X-ray diffraction (XRD), Fourier transform infrared spectroscopy and scanning electron microscopy respectively. XRD study revealed that additives used in the gel-casting process did not influence the phase composition of the investigated materials. The porosity of sintered scaffolds was assessed by the liquid displacement method and found to be 55-6?%. The pores were tailored to spherical shape and size in the range 300-00?nm, feature of utmost interest to clinicians for cell attachment, proliferation and development of soft tissues. Biocompatibility of HA scaffolds was evaluated via hemolysis studies. The results of hemolysis proved the highly biocompatible behavior of the synthesized HA scaffolds.