Acute phase of aortic dissection: a pilot study on CD40L, MPO, and MMP-1, -2, 9 and TIMP-1 circulating levels in elderly patients

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• 作者：E. Vianello ; E. Dozio ; R. Rigolini ; M. M. Marrocco-Trischitta…
• 关键词：Acute aortic dissection (AAD) ; CD40 ligand (CD40L) ; Matrix metalloproteinases (MMPs) ; Metallopeptidase tissue inhibitor 1 (TIMP ; 1) ; Myeloperoxidase (MPO)
• 刊名：Immunity & Ageing
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：13
• 期：1
• 全文大小：413 KB
• 刊物主题：Immunology; Geriatrics/Gerontology; Aging;
• 出版者：BioMed Central
• ISSN：1742-4933

文摘

Background Acute aortic dissection (AAD) is an event which may be rapidly fatal without early diagnosis and treatment. Aging is one of the main risk factors that could leading to AAD. To date, no specific biomarkers are available to increase the speed of diagnosis. CD40 ligand (CD40L), myeloperoxidase (MPO), matrix metalloproteinase (MMP)-1, -2, -9 and metallopeptidase tissue inhibitor 1 (TIMP-1) are biologically related molecules which integrate inflammation, tissue injury and remodeling, all events associated to AAD.