Pathomechanismen und klinische Aspekte der frontotemporalen Lobärdegeneration
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- 作者：K. Bürger ; T. Arzberger ; J. Stephan ; J. Levin ; Prof. Dr. D. Edbauer
- 关键词：SchlüsselwörterNeurodegenerative Erkrankungen ; Frontotemporale Demenz ; Primär progressive Aphasie ; TDP ; 43 ; Proteinopathien ; Tauopathie
- 刊名：Der Nervenarzt
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：88
- 期：2
- 页码：163-172
- 全文大小：788KB
- 刊物主题：Medicine/Public Health, general; Neurology; Neurosurgery; Psychiatry; Psychotherapy;
- 出版者：Springer Medizin
- ISSN：1433-0407
- 卷排序：88
文摘
BackgroundFrontotemporal lobar degeneration (FTLD) includes a spectrum of heterogeneous clinical and neuropathological diseases. In a strict sense this includes the behavioral variant of frontotemporal dementia (bvFTD) and primary progressive aphasia (PPA) and both variants can be associated with amyotrophic lateral sclerosis (FTD-ALS). In a broader sense FTLD also includes progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). In recent years the strong genetic component of FTLD has become increasingly clear.