Is ABCC6 a genuine mitochondrial protein?

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• 作者：Marc Ferré (4) (5)
  Pascal Reynier (4) (5)
  Arnaud Chevrollier (4) (5)
  Delphine Prunier-Mirebeau (4) (5)
  Georges Lefthériotis (5) (5)
  Daniel Henrion (5)
  Dominique Bonneau (4) (5)
  Vincent Procaccio (4) (5)
  Ludovic Martin (5) (5)
  
• 关键词：Mitochondria ; ABCC6/MRP6 ; Pseudoxanthoma elasticum (PXE) ; Mitochondria ; associated membrane (MAM)
• 刊名：BMC Research Notes
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：6
• 期：1
• 全文大小：148 KB
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• 作者单位：Marc Ferré (4) (5)
  Pascal Reynier (4) (5)
  Arnaud Chevrollier (4) (5)
  Delphine Prunier-Mirebeau (4) (5)
  Georges Lefthériotis (5) (5)
  Daniel Henrion (5)
  Dominique Bonneau (4) (5)
  Vincent Procaccio (4) (5)
  Ludovic Martin (5) (5)
  
  4. Department of Biochemistry and Genetics, University Hospital, Angers, France
  5. PXE Consultation Center, University Hospital, Angers, France
  
• ISSN：1756-0500

文摘

Background A recent article in Circulation Research suggests that the protein ABCC6, which when defective is responsible for pseudoxanthoma elasticum, an inherited condition with skin, eye and cardiovascular manifestations, is associated with dysfunction in mitochondria -Martin et al.: ABCC6 Localizes to the Mitochondria-Associated Membrane . Circ Res 2012, 111:516-/strong>520. We present complementary information based on a bioinformatics analysis, which was not performed in the article cited, to examine the suggestion that ABCC6 is localized to mitochondria. Results All the computational strategies and integrative approaches that constitute references in the field indicate that ABCC6 is localized outside of mitochondria. Conclusion Our computational and integrative results, including both experimental and predictive data, show that there is no support in favor of the localization of ABCC6 in mitochondria.