Efficient and expeditious chemoselective BOC protection of amines in catalyst and solvent-free media
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- 作者：Balaga Viswanadham ; Abdul S. Mahomed…
- 关键词：Protection ; N ; BOC ; Catalyst and solvent ; free ; Reaction temperature ; Rotary evaporator
- 刊名：Research on Chemical Intermediates
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：43
- 期：3
- 页码：1355-1363
- 全文大小：
- 刊物类别：Chemistry and Materials Science
- 刊物主题：Catalysis; Physical Chemistry; Inorganic Chemistry;
- 出版者：Springer Netherlands
- ISSN：1568-5675
- 卷排序：43
文摘
A green and eco-friendly route for the almost quantitative BOC protection of a large variety of aliphatic and aromatic amines, amino acids, and amino alcohols is reported in catalyst and solvent-free media under mild reaction conditions. The products were confirmed by 1H, 13C NMR, IR spectroscopy, and in some cases, elemental analysis. This protocol does not require any water quenches, solvent separations, and purification steps, such as recrystallization and column chromatography.