Synthesis and anticancer activity of novel 2-substituted pyranopyridine derivatives
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- 作者：Salwa F. Mohamed ; Eman R. Kotb ; Eman A. Abd El-Meguid…
- 关键词：Chloropyranopyridine ; Hydrazinyls ; Pyrrolinoisoindolines ; Aliphatic and aromatic amines ; Sulfonamides ; Anticancer evaluation
- 刊名：Research on Chemical Intermediates
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：43
- 期：1
- 页码：437-456
- 全文大小：
- 刊物类别：Chemistry and Materials Science
- 刊物主题：Catalysis; Physical Chemistry; Inorganic Chemistry;
- 出版者：Springer Netherlands
- ISSN：1568-5675
- 卷排序：43
文摘
A novel series of 2-aminopyranopyridine derivatives (3–19) were synthesized utilizing 2-chloro-4-(thiophen-2-yl)-7,8-dihydro-5H-pyrano[4,3-b]pyridine-3-carbonitrile (2) as a key starting compound. The structures of the newly synthesized compounds were confirmed on the basis of elemental analyses and infrared (IR), 1H, 13C-nuclear magnetic resonance (NMR) and mass spectra. Anticancer evaluation was carried out for the new derivatives against Hep-G2 (human liver carcinoma), MCF-7 (human breast carcinoma), Caco-2 (human colorectal adenocarcinoma) and HCT116 (human colorectal carcinoma) cell lines using doxorubicin as a reference drug. The biological results revealed that the compounds 12 and 14 exhibited more potent anticancer activity than the reference drug.