Photoactive platinum diimine complexes showing induced cancer cell death by apoptosis

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• 作者：Zhigang Zhang ; Ruihui Dai
• 关键词：Platinum diimine complex ; Photodynamic therapy ; Cytotoxicity ; Cell cycle arrest ; Apoptosis
• 刊名：BioMetals
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：30
• 期：1
• 页码：37-42
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biochemistry, general; Pharmacology/Toxicology; Microbiology; Cell Biology; Plant Physiology; Medicine/Public Health, general;
• 出版者：Springer Netherlands
• ISSN：1572-8773
• 卷排序：30

文摘

Photoinduced cytotoxicity mediated by a triphenylenamine-modified platinum diimine complex in human breast adenocarcinoma cells has been studied by cell viability assay. The triphenylenamine-modified platinum diimine complex showed more potent cytotoxicity in light than its carboxylate-modified analogue. To gain insights into the mechanism of photodynamic activity of this class of platinum diimine complexes, flow cytometric analyses were performed. The results suggest that upon irradiation the two platinum diimine complexes studied could induce cell cycle arrest in G₂/M or S phase, and both of them could induce cancer cell death by apoptosis.