In vitro and in vivo satietogenic effect of yeast extracts and control of food intake in rats

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• 作者：Lucie Catiau (1) Lucie.catiau@gmail.com
  Naima Nedjar-Arroume (1)
  Didier Guillochon (1)
  Rozenn Ravallec (1)
• 关键词：Yeast extract – ; Cholecystokinin – ; Enteroendocrine STC ; 1 cells – ; Bioactive molecules – ; In vivo – ; Rats
• 刊名：European Food Research and Technology
• 出版年：2011
• 出版时间：September 2011
• 年：2011
• 卷：233
• 期：3
• 页码：525-532
• 全文大小：383.5 KB
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• 作者单位：1. ProBioGEM, IUT A鈥擯olytech鈥橪ille, 59655 Villeneuve d鈥橝scq cedex, France
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Food Science
  Analytical Chemistry
  Biotechnology
  Agriculture
  Forestry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1438-2385

文摘

Yeast extracts, by their nutritional characteristics, have a high potential as a source of biologically active molecules and functional food ingredients. In this work, in vitro and in vivo satietogenic effect of yeast extracts was examined. The in vitro results obtained for the first time showed that a yeast extract strongly stimulated the secretion of cholecystokinin (CCK) from endocrine STC-1 cells. The effects obtained with this yeast extract were compared to those obtained with other food products known for their potential involvement in satiety (milk proteins, soybean). This yeast extract showed a stronger ability to stimulate CCK secretion than all other products tested. Lack of toxicity of this yeast extract was demonstrated through cell proliferation assays. In vivo, the tests in rats confirmed the satietogenic potential of this yeast extract, particularly in terms of food intake and weight loss, but also for hormone levels.