CXCL1 promotes arteriogenesis through enhanced monocyte recruitment into the peri-collateral space
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- 作者：Mark H. M. Vries ; Allard Wagenaar ; Sanne E. L. Verbruggen…
- 关键词：Peripheral vascular disease ; Arteriogenesis ; Chemokines ; Endothelial cells ; Monocytes
- 刊名：Angiogenesis
- 出版年：2015
- 出版时间：April 2015
- 年：2015
- 卷：18
- 期：2
- 页码：163-171
- 全文大小：770 KB
- 参考文献：1. Schaper, W, Schaper, J (2004) Arteriogenesis. Kluwer Academic Publishers Group, Boston CrossRef
2. Heil, M, Eitenmuller, I, Schmitz-Rixen, T, Schaper, W (2006) Arteriogenesis versus angiogenesis: similarities and differences. J Cell Mol Med 10: pp. 45-55 CrossRef
3. Vogel, R, Traupe, T, Steiger, VS, Seiler, C (2010) Physical coronary arteriogenesis: a human “model-of collateral growth promotion. Trends Cardiovasc Med 20: pp. 129-133 CrossRef
4. Jain, RK (2003) Molecular regulation of vessel maturation. Nat Med 9: pp. 685-693 CrossRef
5. Schirmer, SH, Nooijen, FC, Piek, JJ, Royen, N (2009) Stimulation of collateral artery growth: travelling further down the road to clinical application. Heart 95: pp. 191-197 CrossRef
6. Hoefer, IE, Grundmann, S, Royen, N, Voskuil, M, Schirmer, SH, Ulusans, S, Bode, C, Buschmann, IR, Piek, JJ (2005) Leukocyte subpopulations and arteriogenesis: specific role of monocytes, lymphocytes and granulocytes. Atherosclerosis 181: pp. 285-293 CrossRef
7. Takeda, Y, Costa, S, Delamarre, E, Roncal, C, Oliveira, RL, Squadrito, ML, Finisguerra, V, Deschoemaeker, S, Bruyere, F, Wenes, M, Hamm, A, Serneels, J, Magat, J, Bhattacharyya, T, Anisimov, A, Jordan, BF, Alitalo, K, Maxwell, P, Gallez, B, Zhuang, ZW, Saito, Y, Simons, M, Palma, M, Mazzone, M (2011) Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis. Nature 479: pp. 122-126 CrossRef
8. Addison, CL, Daniel, TO, Burdick, MD, Liu, H, Ehlert, JE, Xue, YY, Buechi, L, Walz, A, Richmond, A, Strieter, RM (2000) The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity. J Immunol 165: pp. 5269-5277 CrossRef
9. Hagiwara, H, Mitsumata, M, Yamane, T, Jin, X, Yoshida, Y (1998) Laminar shear stress-induced GRO mRNA and protein expression in endothelial cells. Circulation 98: pp. 2584-2590 CrossRef
10. Bozic, CR, Gerard, NP, Uexkull-Guldenband, C, Kolakowski, LF, Conklyn, MJ, Breslow, R, Showell, HJ, Gerard, C (1994) The murine interleukin 8 type B receptor homologue and its ligands. Expression and biological characterization. J Biol Chem 269: pp. 29355-29358
11. White, JR, Lee, JM, Young, PR, Hertzberg, RP, Jurewicz, AJ, Chaikin, MA, Widdowson, K, Foley, JJ, Martin, LD, Griswold, DE, Sarau, HM (1998) Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem 273: pp. 10095-10098 CrossRef
12. Ito, WD, Arras, M, Winkler, B, Scholz, D, Schaper, J, Schaper, W (1997) Monocyte chemotactic protein-1 increases collateral and peripheral conductance after femoral artery occlusion. Circ Res 80: pp. 829-837 CrossRef
13. Scholz, D, Ziegelhoeffer, T, Helisch, A, Wagner, S, Friedrich, C, Podzuweit, T, Schaper, W (2002) Contribution of arteriogenesis and angiogenesis to postocclusive hindlimb perfusion in mice. J Mol Cell Cardiol 34: pp. 775-787 CrossRef
14. Gordon, S, Taylor, PR (2005) Monocyte and macrophage heterogeneity. Nat Rev Immunol 5: pp. 953-964 CrossRef
15. Wang, D, Wang, H, Brown, J, Daikoku, T, Ning, W, Shi, Q, Richmond, A, Strieter, R, Dey, SK, DuBois, RN (2006) CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer. J Exp Med 203: pp. 941-951
文摘
Aims The mechanisms of monocyte recruitment to arteriogenic collaterals are largely unknown. We investigated the role of chemokine (C-X-C-motif) ligand 1 (CXCL1) and its cognate receptor, chemokine (C-X-C-motif) receptor 2 (CXCR2) in arteriogenesis. Methods and results After femoral artery ligation in Sprague–Dawley rats, either native collaterals were harvested or placebo, CXCL1 or CXCR2 blocker was administered via an osmopump. Perfusion recovery was measured with Laser Doppler, leukocyte populations were analyzed by fluorescence-activated cell sorting, and hind limb sections were stained for macrophage marker cluster of differentiation 68 (CD68). In vitro, fluorescent CXCL1 or human acute monocytic leukemia cell line (THP-1) monocytic cells were flown over shear-stressed endothelium. CXCL1 mRNA expression in collaterals was dramatically upregulated already 1?h after ligation (ratio ligated/sham 5.73). CD68 mRNA was upregulated from 12?h until 3?days after ligation (peak ratio ligated/sham 2.65). CXCL1 treatment augmented perfusion recovery at 3 and 7?days (p?p?p?=?0.01) and also significantly reduced the number of peri-collateral macrophages (p?p?p? Conclusion CXCL1 presented on the luminal endothelial surface leads to an increase in the number of peri-collateral macrophages, thus improving the arteriogenic response after arterial ligation.