Pleiotropic effects of herbs characterized with blood-activating and stasis-resolving functions on angiogenesis
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- 作者：Li Tao 陶 丽 ; Sheng Wang 王 生 ; Yang Zhao 赵 杨…
- 关键词：blood activating and stasis resolving ; Chinese medicine ; pro ; angiogenesis ; anti ; angiogenesis ; physiological angiogenesis ; pathological angiogenesis ; arteriogenesis
- 刊名：Chinese Journal of Integrative Medicine
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：22
- 期：10
- 页码：795-800
- 全文大小：468 KB
- 刊物主题：Medicine/Public Health, general;
- 出版者：Springer Berlin Heidelberg
- ISSN：1993-0402
- 卷排序：22
文摘
Accumulative evidences have underpinned the nature candidates from Chinese medicine (CM), particularly CM served as blood activating and stasis resolving (BASR, Huoxue Huayu in Chinese) by targeting tumor-associated angiogenesis. However, recent experiment research on the therapeutic angiogenesis by BASR-CM attracts wide attention and discussion. This opinion review focused on the underlying link between two indications and anticipated that (1) BASR-CM might emphasize on a balanced multi-cytokines network interaction; (2) BASR-CM might address on the nature of diseases prior to differently affecting physiological and pathological angiogenesis; (3) BASR-CM might mainly act on perivascular cells, either promotes arteriogenesis by increasing arteriogenic factors in ischemic diseases, or simultaneously keep a quiescent vasculature to impede angiogenesis in tumor context.