Reactions of 2-Arylhydrazonoacetamides with Orthoesters. Synthesis of New Tetrahydro-1,2,4-triazines

详细信息    查看全文

• 作者：N. P. Bel'skaya ; E. E. Zvereva ; L. A. Babushkina and V. A. Bakulev
• 关键词：arylhydrazones ; orthoesters ; tetrahydrotriazinones
• 刊名：Chemistry of Heterocyclic Compounds
• 出版年：2000
• 出版时间：2000
• 年：2000
• 卷：36
• 期：9
• 页码：1066-1076
• 全文大小：141 KB

文摘

The reactions of arylhydrazonocyanoacetamides with triethyl orthoformate and triethyl orthoacetate have been studied. Interaction of triethyl orthoformate with amides bearing normal alkyl substituents on the carbamoyl group resulted in cyclization to 2-aryl-4-alkyl-5-oxo-3-ethoxy-2,3,4,5-tetrahydro-1,2,4-triazin-6-carbonitriles, whereas reaction of N-phenyl- and N-cycloalkylacetamides with triethyl orthoformate gave products of ethylation at the hydrazone group. Reactions of arylhydrazonocyanoacetamides with triethyl orthoacetate led to 2-(arylethylhydrazono)acetamides exclusively.