A Combination of a Dairy Product Fermented by Lactobacilli and Galactooligosaccharides Shows Additive Effects on Mineral Balances in Growing Rats with Hypochlorhydria Induced by a Proton Pump Inhibitor
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- 作者：Satoshi Takasugi (1)
Kinya Ashida (1)
Suyaka Maruyama (1)
Yukari Matsukiyo (1)
Tetsuo Kaneko (1)
Taketo Yamaji (1) - 关键词：Hypochlorhydria ; Fermented milk ; Galactooligosaccharides ; Mineral balance ; Bone strength ; PPI
- 刊名：Biological Trace Element Research
- 出版年：2013
- 出版时间：June 2013
- 年：2013
- 卷：153
- 期：1-3
- 页码：309-318
- 全文大小：173KB
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Kinya Ashida (1)
Suyaka Maruyama (1)
Yukari Matsukiyo (1)
Tetsuo Kaneko (1)
Taketo Yamaji (1)
1. Food Science Research Laboratories, Division of Research and Development, Meiji Co., Ltd., 540 Naruda, Odawara, Kanagawa, 250-0862, Japan
文摘
This study aimed to investigate the effects of a combination of a dairy product fermented by lactobacilli (DFL) and galactooligosaccharides (GOS) on mineral balances in growing rats with hypochlorhydria induced by a proton pump inhibitor (PPI). Three-week-old male rats were assigned to receive one of six diets: a control diet, control diets containing 1.6 or 5.0?% GOS, a DFL diet and DFL diets containing 1.6 or 5.0?% GOS for 9?days. From day 5 of the feeding period, half of the rats fed with control diets were subcutaneously administered with saline, whereas the remaining rats were administered with PPI for 5?days. Calcium (Ca), phosphorus (P), magnesium (Mg), iron (Fe) and zinc (Zn) balances were determined from days 6 to 9. PPI administration significantly decreased the apparent absorption of Ca and Fe and increased urinary P excretion, resulting in decreased Ca, Fe and P retention. GOS dose-dependently increased the apparent absorption of Ca, Mg and Fe and urinary Mg excretion and decreased urinary P excretion. DFL significantly increased the apparent absorption of Ca and Mg and urinary Mg excretion. The combination of DFL and GOS additively affected these parameters, resulting in increased Ca, P and Fe retention, and it further increased the apparent absorption and retention of Zn at 5.0?% GOS. In conclusion, the combination of DFL and GOS improves Ca, P and Fe retention in an additive manner and increases the Zn retention in growing rats with hypochlorhydria induced by PPI.