Subclinical non-autoimmune hypothyroidism in children with steroid resistant nephrotic syndrome

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• 作者：Kanika Kapoor (1)
  Abhijeet Saha (1)
  N. K. Dubey (1)
  Parul Goyal (2)
  C. P. Suresh (1)
  Vinita Batra (3)
  Ashish Dutt Upadhayay (4)
  
• 关键词：Hypothyroidism ; Children ; Nephrotic syndrome
• 刊名：Clinical and Experimental Nephrology
• 出版年：2014
• 出版时间：February 2014
• 年：2014
• 卷：18
• 期：1
• 页码：113-117
• 全文大小：173 KB
• 作者单位：Kanika Kapoor (1)
  Abhijeet Saha (1)
  N. K. Dubey (1)
  Parul Goyal (2)
  C. P. Suresh (1)
  Vinita Batra (3)
  Ashish Dutt Upadhayay (4)
  
  1. Department of Pediatrics, Postgraduate Institute of Medical Education and Research associated Dr Ram Manohar Lohia Hospital, Room no 406, PGIMER Building, New Delhi, 201010, India
  2. Department of Biochemistry, Postgraduate Institute of Medical Education and Research associated Dr Ram Manohar Lohia Hospital, New Delhi, India
  3. Department of Pathology, GB Pant Hospital, New Delhi, India
  4. Department of Biostatistics, AIIMS, New Delhi, India
  
• ISSN：1437-7799

文摘

Background Thyroid status has not been studied well in children with steroid resistant nephrotic syndrome (SRNS). Methods In this cross sectional study we recruited 20 children aged 1-6?years with SRNS and similar number of controls. Serum levels of FT3, FT4 and TSH were measured in all the subjects. Overt hypothyroidism was defined as low FT4 (normal values: 0.7-.0?ng/mL) and elevated serum TSH above reference values (0.45-.5?mIU/L). Subclinical hypothyroidism (SH) was defined as an elevation in serum TSH with a normal serum FT4 concentration. The primary outcome measure was serum levels of FT3, FT4 and TSH in children with SRNS. Results Thirty per cent of the children (n?=?6) with SRNS had non-autoimmune subclinical hypothyroidism (2 children each with grade I, II and III). Children with SRNS had a median TSH value [3.9?mIU/L (0.5-3)] within normal range, but levels were high as compared to controls. Out of 6 children with SH, 3 were in partial remission, 3 were in complete remission. The TSH levels normalized on thyroxine supplementation in grades II and III subclinical hypothyroidism. Conclusion Subclinical non-autoimmune hypothyroidism is present in a significant proportion of children with SRNS despite partial or complete remission. Thyroid profile should be evaluated routinely in this subset of patients.