Anti-Radical and Cytotoxic Activity of Polysuccinimide and Polyaspartic Acid of Different Molecular Weight

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• 作者：Diana Vitalevna Salakhieva ; D. R. Gumerova ; R. A. Akhmadishina…
• 关键词：Poly(succinimide) ; Poly(aspartic acid) ; Molecular weight ; Free radicals ; Cytotoxicity
• 刊名：BioNanoScience
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：6
• 期：4
• 页码：348-351
• 全文大小：
• 刊物主题：Circuits and Systems; Biological and Medical Physics, Biophysics; Nanotechnology; Biomaterials;
• 出版者：Springer US
• ISSN：2191-1649
• 卷排序：6

文摘

Effect of poly(succinimide) (PSI) and poly(aspartic acid) (PASP) on free radical reactions and cell viability was assessed. Molecular weight (MW) of PASPs was determined by static light scattering technique and found as 3.9 and 8.3 kDa. Among PSIs and PASPs, only poly(aspartic acid) with higher MW was found to inhibit formation of hydroxyl-radical in Fenton’s reaction, although each polymers studied were not able to eliminate diphenylpicrylhydrazyl radical. PASPs were almost non-toxic for 3 T3 fibroblasts and PC-3 cells (IC₅₀ ≫ 3 mg/mL), whereas PSIs diminished cell viability with different IC₅₀ values depending on cell type and polymer MW. Our preliminary data indicate the MW dependence of bioactivity of l-aspartic acid-derived polymers designed as drug carriers and biocompatible materials.