Altered Sigma-1 Receptor Expression in Two Animal Models of Cognitive Impairment

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• 作者：Nisha K. Ramakrishnan ; Krisztina Marosi ; Csaba J. Nyakas…
• 关键词：Cholinergic lesion ; microPET ; Novel object recognition ; Passive avoidance ; REM sleep deprivation ; [11C]SA4503 ; Sigma ; 1 receptor
• 刊名：Molecular Imaging and Biology
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：17
• 期：2
• 页码：231-238
• 全文大小：679 KB
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• 刊物主题：Imaging / Radiology;
• 出版者：Springer US
• ISSN：1860-2002

文摘

Purpose Sigma-1 receptors are involved in learning and memory processes. We assessed sigma-1 receptor expression and memory function in two animal models of cognitive impairment. Procedures Male Wistar-Hannover rats were either lesioned by unilateral injection of N-methyl-D-aspartic acid in the nucleus basalis, or deprived of rapid eye movement sleep for 48?h, using the modified multiple platform method. Sigma-1 receptor expression was examined with the positron emission tomography radiotracer [11C]SA4503, immunohistochemistry, and Western blotting. Results Cortical tracer uptake after 1?week was not significantly affected by lesioning. Immunohistochemistry revealed moderate increases of sigma-1 receptors at bregma level ?.8, in parietal cortex layer V of the lesioned hemisphere. Sleep deprivation lowered passive avoidance test scores and reduced [11C]SA4503 accumulation and sigma-1 receptor expression in pons. Conclusions Cholinergic lesioning causes an increase of sigma-1 receptor expression in a small cortical area which may be neuroprotective. Sleep deprivation decreases receptor expression in midbrain and pons.