Protective Effect of Astragaloside IV Against Paraquat-Induced Lung Injury in Mice by Suppressing Rho Signaling

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• 作者：Tong Chen ; Ruoning Wang ; Wenjiao Jiang ; Huimin Wang ; Ang Xu ; Guo Lu ; Yi Ren…
• 关键词：astragaloside IV ; paraquat ; lung injury ; Rho ; Txnip/Trx
• 刊名：Inflammation
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：39
• 期：1
• 页码：483-492
• 全文大小：1,863 KB
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• 作者单位：Tong Chen (1)
  Ruoning Wang (1)
  Wenjiao Jiang (1)
  Huimin Wang (2)
  Ang Xu (1)
  Guo Lu (1)
  Yi Ren (1)
  Yangmei Xu (1)
  Yangyang Song (1)
  Shoulei Yong (2)
  Hui Ji (1)
  Zhanqiang Ma (1) (3)
  
  1. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China
  2. School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China
  3. Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, 210009, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Rheumatology
  Internal Medicine
  Pharmacology and Toxicology
  Pathology
  
• 出版者：Springer Netherlands
• ISSN：1573-2576

文摘

The purpose of the present study was to evaluate the protective effects of astragaloside IV (AS IV) against paraquat (PQ)-induced pulmonary injury in vivo. Fifty BALB/C mice were randomized into five groups: (1) control, (2) PQ, (3) PQ + dexamethasone (Dex, 5 mg/kg), (4) PQ + AS IV (50 mg/kg), and (5) PQ + AS IV (100 mg/kg). A single dose of PQ (50 mg/kg, i.p.) was intraperitoneally given to induced acute lung injury. Then, mice were treated with AS IV (50 and 100 mg/kg/day, orally) for 5 days. At the end of the experiment, animals were euthanized; then, the bronchoalveolar lavage fluid (BALF) and lung tissues were collected for histological observation, biochemical assay, and Western blot analysis. Malondialdehyde (MDA), myeloperoxidase (MPO), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) in lung tissues, and interleukin-6 (IL-6), IL-1β, tumor necrosis factor-α (TNF-α) levels in BALF were determined. Histological examination indicated that AS IV attenuated lung damage caused by PQ. Biochemical results showed that AS IV treatment significantly reduced the levels of MDA, MPO, and inflammatory cytokines while increased the levels of SOD, CAT, and GSH-Px compared with those in PQ group. Western blot results revealed that AS IV attenuated the Txnip/Trx expressions and inhibited Rho/ROCK/nuclear factor kappaB (NF-κB) signaling pathway in PQ-challenged mice. These findings suggested the protective effect of AS IV as a natural product on PQ-induced pulmonary injury. KEY WORDS astragaloside IV paraquat lung injury Rho Txnip/Trx