Selective Determination of Atropine Using poly Dopamine-Coated Molecularly Imprinted Mn-Doped ZnS Quantum Dots

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• 作者：Javad Abbasifar ; Abdolraouf Samadi-Maybodi
• 刊名：Journal of Fluorescence
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：26
• 期：5
• 页码：1645-1652
• 全文大小：990 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Biomedicine
  Biophysics and Biomedical Physics
  Biotechnology
  Biochemistry
  Analytical Chemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-4994
• 卷排序：26

文摘

In this study, a selective method for the determination of atropine in pharmaceutical formulations was proposed. L-cysteine capped Mn-doped ZnS quantum dots (QDs) were prepared in an in-situ method using sodium thiosulfate precursor and characterized by spectrofluorometer, Fourier transform infrared spectroscopy (FT-IR), transmission electron microscope (TEM) and X-ray diffractometer (XRD). Dopamine hydrochloride was used as a precursor for preparation of poly dopamine-coated molecularly imprinted Mn-doped ZnS quantum dots. Finally, these prepared molecularly imprinted Mn-doped ZnS quantum dots were used for determination of atropine in pharmaceutical formulations. The obtained linear range for determination of atropine was in the range of 2 × 10−8 – 7 × 10−6 M, with a correlation coefficient (R2) of 0.9889; and the detection limit (S/N = 3) was 3.2 nM.KeywordsAtropineMolecularly imprinted polymersQuantum dotsPoly dopamineMn-dopped ZnS